Age-related changes of collagenous fibers in the human vocal fold mucosa
Age-related changes of collagenous fibers in the human vocal fold mucosa
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DOI：
10.1177/000348940211100103
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发表时间：
2002-01-01
影响因子：
1.4
通讯作者：
Nakashima, T
中科院分区：
文献类型：
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作者：
Sato, K;Hirano, M;Nakashima, T
声带粘膜的粘弹性依赖于细胞外基质。胶原纤维提供拉伸强度和弹性，并在细胞外基质中充当稳定支架。在离体正常成人喉标本上，用光镜和电镜观察了声带粘膜中的钩状纤维的增龄性变化。对12例人声带粘膜进行了检查（10例来自70 - 97岁的老年人，2例来自年轻人）。老化粘膜的结果可总结如下。1)特别是在男性中，胶原纤维增加，网状纤维减少。2)胶原纤维成束，密度高。3)胶原纤维之间的间隙和其他细胞外基质的间隙减少。4)胶原原纤维直径不等，外形规则。5)存在扭曲的胶原原纤维。6)偶见大量致密的胶原纤维和纤维组织。7)偶见粘膜深层至浅层胶原纤维增多。不仅胶原纤维的三维结构发生变化，而且胶原纤维的质和量的变化也对细胞外基质的三维结构产生影响。因此，粘弹性必须改变，以确保正常的发声，而这种粘弹性的变化可以解释声音老化的一个组成部分。
The viscoclastic properties of the vocal fold mucosa depend on the extracellular matrices. Collagenous fibers provide tensile strength and resilience and serve as a stabilizing scaffold in the extracellular matrices. Light and electron microscopic investigations of age-related changes of cullagenous fibers in vocal fold mucosa were carried out on excised normal human adult larynges. Twelve human vocal fold mucosac were examined (10 from older adults with ages ranging from 70 to 97 years, and 2 from younger adults for comparison). The results for the aged mucosae can be summarized as follows. 1) Especially in men, collagenous fibers had increased and reticular fibers had decreased. 2) Collagenous fibers had formed bundles, and their density was high. 3) The spaces between collagenous fibers and the interstitial spaces for other extracellular matrices had decreased. 4) The collagenous fibril diameters differed, and their outline was it-regular. 5) Twisted collagenous fibrils were present. 6) Occasionally, masses of dense collagenous fibers and fibrous tissue could be seen in the mucosa. 7) Occasionally, the collagenous fibers were increased all the way from the deep layer to the superficial layer of the mucosa. and consequently, there was no layered structure, Not only changes in the 3-dimensional structure of the collagenous fibers, but also their qualitative and quantitative changes, have an effect on the 3-dimensional structure of the extracellular matrices. Thus, the viscoelasticity must change to ensure normal phonation, and this change in viscoclasticity would explain one component of aging of the voice.