Asthma and Mood Disorders.
Asthma and Mood Disorders.
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DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
A. Kewalramani;M. Bollinger;T. Postolache,
中科院分区：
文献类型：
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作者：
A. Kewalramani;M. Bollinger;T. Postolache,
哮喘和情绪障碍的高并发率意味着潜在的共同病理生理因素的可能性。哮喘和情绪障碍之间的拟议联系包括脆弱性（特质）和状态联系。哮喘和情绪障碍的易感性可能与遗传和早期发育因素有关。与状态相关的联系可能包括阻塞因素、炎症因素、睡眠障碍、慢性疾病的心理反应，以及患有慢性压力的个体哮喘恶化。哮喘治疗也可能加剧情绪障碍。新研究表明中枢神经系统与哮喘和过敏有关。需要进一步表征哮喘和情绪障碍之间的临床、心理、细胞和分子相互关系，以更好地评估和治疗这些患者。心理健康专业人员和过敏症专家之间的密切合作可以改善症状控制、生活质量、整体功能并最终降低死亡率。
The high rate of comorbidity of asthma and mood disorders would imply the possibility of potential shared pathophysiologic factors. Proposed links between asthma and mood disorders include a vulnerability (trait) and state connection. Vulnerability for both asthma and mood disorders may involve genetic and early developmental factors. State-related connections may include obstructive factors, inflammatory factors, sleep impairment, psychological reactions to chronic medical illness, as well as exacerbation of asthma in individuals with chronic stress. Treatment for asthma may also exacerbate mood disorders. New research suggests involvement of the central nervous system in asthma and allergy. Further characterization of clinical, psychological, cellular and molecular interconnections between asthma and mood disorders is needed to better evaluate and treat these patients. A close collaboration between mental health professionals and allergists could result in improved symptom control, quality of life, overall functioning and ultimately, decreased mortality.