AGE DISTRIBUTION OF THE ANTIBODY TO TYPE-C INFLUENZA-VIRUS
AGE DISTRIBUTION OF THE ANTIBODY TO TYPE-C INFLUENZA-VIRUS
复制标题
DOI：
10.1111/mim.1982.26.7.639
复制
发表时间：
1982-01-01
影响因子：
2.6
通讯作者：
KATAGIRI, S
中科院分区：
文献类型：
--
作者：
HOMMA, M;OHYAMA, S;KATAGIRI, S
在日本进行的丙型流感病毒感染的血清流行病学调查中，1976年从186名0-80岁的健康受试者中收集了血清，1979年又收集了434份血清样本。对这些样本进行了C/青森/74型流感病毒血凝抑制抗体检测。低滴度的抗体存在于所有婴儿年龄小于2个月，但发病率，这可能是母亲，抗体下降到零，在婴儿年龄6个月。3岁以上儿童的抗体阳性血清比例迅速增加，达到7-10岁儿童血清的80-90%。在老年人中，阳性血清比例增加较慢，几乎达到100%：30岁以上受试者的254份血清中只有5份呈血清阴性。这些高水平的发病率和抗体滴度都维持在70岁以上。在1976年收集的血清和1979年收集的血清之间，抗体的年龄分布没有显着差异。这些结果与英国、美国和其他国家的报道相似。Boulter
In a seroepidemiological survey of influenza C virus infection in Japan sera were collected from 186 healthy subjects aged 0-80 years in 1976, and a further sample of 434 sera was collected in 1979. These were tested for haemagglutination-inhibiting antibodies to influenza C/Aomori/74 virus. Low titres of antibody were present in all infants aged less than 2 months, but the incidence of this, presumably maternal, antibody fell to zero in infants aged 6 months. The proportion of antibody-positive sera increased rapidly in children aged over 3 years to reach 80-90% of sera from those aged 7-10 years. In older people there was a slower increase in the proportion of positive sera to almost 100%: only 5 of 254 sera from subjects aged over 30 years were seronegative. These high levels of both incidence and titres of antibody were maintained beyond the age of 70 years. No significant differences in the age-distribution of antibodies were found between sera collected in 1976 and those collected in 1979. These results are similar to those reported from England, the USA and other countries.E.A. Boulter