Evidence synthesis in prognosis research.
Evidence synthesis in prognosis research.
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DOI：
10.1186/s41512-019-0059-4
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发表时间：
2019-01-01
影响因子：
--
通讯作者：
Riley, Richard D
中科院分区：
文献类型：
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作者：
Debray, Thomas P A;de Jong, Valentijn M T;Riley, Richard D
Over the past few years, evidence synthesis has become essential to investigate and improve the generalizability of medical research findings. This strategy often involves a meta-analysis to formally summarize quantities of interest, such as relative treatment effect estimates. The use of meta-analysis methods is, however, less straightforward in prognosis research because substantial variation exists in research objectives, analysis methods and the level of reported evidence. We present a gentle overview of statistical methods that can be used to summarize data of prognostic factor and prognostic model studies. We discuss how aggregate data, individual participant data, or a combination thereof can be combined through meta-analysis methods. Recent examples are provided throughout to illustrate the various methods.
