Renal vascular responses in spontaneously hypertensive rats chronically treated with manidipine.
Renal vascular responses in spontaneously hypertensive rats chronically treated with manidipine.
复制标题
长期用马尼地平治疗的自发性高血压大鼠的肾血管反应。
DOI：
--
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
K. Fukiyama
中科院分区：
文献类型：
--
作者：
H. Muratani;S. Takishita;N. Kawazoe;M. Tozawa;K. Fukiyama
情绪应激时肾血管收缩反应增强可能与原发性高血压的发病机制有关。我们研究了慢性马尼地平治疗对清醒的自发性高血压大鼠（SHR）的肾血流（RBF）对空气喷射应激、血管紧张素II（ANG II）和内皮素-3（ET-3）的反应的影响。将雄性SHR置于对照饮食或含有0.05%马尼地平的饮食4周。以对照饮食喂养的Wistar-Kyoto（WKY）大鼠作为血压正常的对照。与对照SHR相比，马尼地平降低血压（p < 0.01），增加尿钠排泄（p < 0.01），并降低体重（p < 0.01）。空气喷射压力升高动脉压和增加RBF。对照组SHR的升压反应明显高于WKY组（P < 0.01），马尼地平对升压反应无影响。马尼地平处理的SHR中RBF的百分比下降（-16%）小于对照SHR中的百分比下降（-30%，p < 0.05），并且与WKY大鼠中的百分比下降（-18%）相似。相反，ANG II（0.1 nmol/kg/min）引起的升压效应和RBF下降百分比在三组中相似。静脉注射ET-3（1 nmol/kg）引起一过性下降，随后全身血压持续升高，两者均与RBF降低相关。与WKY相比，SHR的RBF对ET-3的反应减弱，马尼地平治疗没有改变。这些结果表明，抗高血压治疗与马尼地平可能是有益的，在维持RBF在情绪应激。
An enhanced renal vasoconstrictive response to emotional stress may be related to the pathogenesis of essential hypertension. We examined the effects of chronic manidipine treatment on renal blood flow (RBF) responses to air jet stress, angiotensin II (ANG II), and endothelin-3 (ET-3) in the conscious unrestrained spontaneously hypertensive rat (SHR). Male SHRs were placed on a control diet or one containing 0.05% of manidipine for 4 weeks. Age-matched Wistar-Kyoto (WKY) rats placed on a control diet served as normotensive controls. In comparison with control SHRs, manidipine reduced blood pressure (p < 0.01), increased urinary sodium excretion (p < 0.01), and reduced body weight (p < 0.01). Air jet stress elevated arterial pressure and increased RBF. The pressor response was enhanced more in the control SHRs than in the WKY rats (p < 0.01) and was not altered by manidipine. The percent fall in RBF in the manidipine-treated SHRs (-16%) was less than that in the control SHRs (-30%, p < 0.05) and similar to that in the WKY rats (-18%). In contrast, the pressor effect and the percent fall in RBF caused by ANG II (0.1 nmol/kg/min) were similar in the three groups. Intravenous ET-3 (1 nmol/kg) caused a transient fall, followed by a sustained increase in systemic blood pressure, both of which were associated with a decrease in RBF. The RBF response to ET-3 was blunted in SHRs compared to WKYs and was not altered by manidipine treatment. These results suggest that antihypertensive therapy with manidipine may be beneficial in maintaining RBF during emotional stress.