Population Epigenetics.
Population Epigenetics.
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DOI：
10.1016/j.coisb.2017.01.004
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发表时间：
2017-02-01
影响因子：
3.7
通讯作者：
Greally, John M
中科院分区：
文献类型：
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作者：
Greally, John M
表观遗传学领域正在成熟，人们对理解基因组的正常调节以及作为疾病表型原因的一部分而异常重编程的可能性越来越感兴趣。将当前的技术和见解应用于人群研究可能是理解这些疾病的机制和后果的一种方式。当扩展到包括医疗保健差异，了解为什么某些人群异常容易出现特定疾病时，肯定有一些获得新的和有价值的见解的潜力，但这些研究可能异常容易受到混杂影响的影响，需要特别小心地设计，执行和解释。
The field of epigenetics is maturing, with increased interest in understanding the normal regulation of the genome and the possibility that it becomes reprogrammed aberrantly as part of the cause of disease phenotypes. Applying the current technologies and insights to the study of human populations is potentially a way of understanding mechanisms and consequences of these diseases. When extended to encompass health care disparities, understanding why certain populations are unusually prone to specific conditions, there is certainly some potential for gaining new and valuable insights, but these studies are likely to be unusually prone to the effects of confounding influences and need to be designed, executed and interpreted with extra care.