3,4-Methylenedioxymethamphetamine (MDMA) alters acute gammaherpesvirus burden and limits interleukin 27 responses in a mouse model of viral infection.
3,4-Methylenedioxymethamphetamine (MDMA) alters acute gammaherpesvirus burden and limits interleukin 27 responses in a mouse model of viral infection.
复制标题
DOI：
10.1016/j.drugalcdep.2010.12.019
复制
发表时间：
2011-07-01
影响因子：
4.2
通讯作者：
Bost, Kenneth L.
中科院分区：
文献类型：
--
作者：
Nelson, Daniel A.;Singh, Sam J.;Young, Amy B.;Tolbert, Melanie D.;Bost, Kenneth L.
检测3，4-亚甲二氧基甲基苯丙胺（MDMA，“摇头丸”）滥用是否可能增加对小鼠γ疱疹病毒68（HV-68）和/或细菌脂多糖的易感性或改变免疫应答。对实验组和对照组小鼠进行为期三天的MDMA狂欢，并评估该药物滥用对急性和潜伏HV-68病毒负荷的影响。还进行了体外和体内研究，以评估MDMA对病毒感染或LPS暴露的巨噬细胞和树突细胞以及暴露于该滥用药物的潜伏感染动物中IL-27表达的影响。与对照组相比，MDMA处理小鼠的急性病毒负荷显著增加。然而，尽管反复狂饮MDMA，但感染小鼠的潜伏病毒负荷以及生理和行为反应并未改变。MDMA可限制体外和体内HV-68感染或LPS暴露的巨噬细胞和树突状细胞的IL-27应答，证明该药物能够在病毒感染和/或TLR 4激动剂的情况下改变正常细胞因子应答。MDMA暴食可改变宿主的免疫反应，导致更大的急性病毒复制和免疫反应期间细胞因子IL-27的产生减少。
To test whether 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) abuse might increase the susceptibility, or alter the immune response, to murine gammaherpesvirus 68 (HV-68) and/or bacterial lipopolysaccharide. Groups of experimental and control mice were subjected to three day binges of MDMA, and the effect of this drug abuse on acute and latent HV-68 viral burden were assessed. In vitro and in vivo studies were also performed to assess the MDMA effect on IL-27 expression in virally infected or LPS-exposed macrophages and dendritic cells, and latently infected animals, exposed to this drug of abuse. Acute viral burden was significantly increased in MDMA-treated mice when compared to controls. However the latent viral burden, and physiological and behavioral responses were not altered in infected mice despite repeated bingeing with MDMA. MDMA could limit the IL-27 response of HV-68 infected or LPS-exposed macrophages and dendritic cells in vitro and in vivo, demonstrating the ability of this drug to alter normal cytokine responses in the context of a viral infection and/or a TLR4 agonist. MDMA bingeing could alter the host’s immune response resulting in greater acute viral replication and reductions in the production of the cytokine, IL-27 during immune responses.
登录
查看更多内容
影响因子：
15.3
作者：
Liu, Jianguo;Guan, Xiuqin;Ma, Xiaojing
通讯作者：
Ma, Xiaojing
影响因子：
3.5
作者：
Mockridge, CI;Rahman, A;Potter, KN
通讯作者：
Potter, KN
影响因子：
4.4
作者：
Bowman, CC;Bost, KL
通讯作者：
Bost, KL
影响因子：
5
作者：
Boyle, Noreen T.;Connor, Thomas J.
通讯作者：
Connor, Thomas J.
影响因子：
4.4
作者：
Gasper-Smith, Nancy;Marriott, Ian;Bost, Kenneth L.
通讯作者：
Bost, Kenneth L.