The Chd family of chromatin remodelers
The Chd family of chromatin remodelers
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DOI：
10.1016/j.mrfmmm.2006.07.012
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发表时间：
2007-05-01
影响因子：
2.3
通讯作者：
Imbalzano, Anthony N.
中科院分区：
文献类型：
--
作者：
Marfella, Concetta G. A.;Imbalzano, Anthony N.
染色质重塑酶有助于在细胞过程如转录、重组、修复和复制期间发生在染色质结构中的动态变化。染色体结构域解旋酶DNA结合（Chd）酶家族的成员属于ATP依赖性染色质重塑的SNF 2超家族。Chd蛋白的区别在于存在两个N-末端chromodomains，其作为各种染色质组分的相互作用表面。遗传、生化和结构研究表明，Chd蛋白是重要的转录调节因子，在发育过程中起着关键作用。许多Chd蛋白也与人类疾病有关。(C)2007 Elsevier B. V.保留所有权利。
Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease. (C) 2007 Elsevier B.V. All rights reserved.