Nicotine Behavioral Sensitization in Lewis and Fischer Male Rats
Nicotine Behavioral Sensitization in Lewis and Fischer Male Rats
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DOI：
10.1037/a0029088
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发表时间：
2012-10-01
影响因子：
2.3
通讯作者：
Grunberg, Neil E.
中科院分区：
文献类型：
--
作者：
Hamilton, Kristen R.;Starosciak, Amy K.;Grunberg, Neil E.
尼古丁反应性较高的个体可能比尼古丁反应性较低的个体更容易开始并维持吸烟行为。在大鼠中，行为敏化反映了对滥用药物的精神反应的逐步增加，这被认为是由大脑区域的神经可塑性引起的，这些区域介导了药物的动机效应。研究不同尼古丁偏好和摄入的大鼠（如刘易斯和费舍尔大鼠）的尼古丁行为敏化，可能会为尼古丁反应性在烟草使用中的作用提供线索。大鼠尼古丁行为敏感性的品系差异可能导致尼古丁偏好、敏感性和摄入量的品系差异。在本研究中，在刘易斯和费舍尔大鼠中检查了尼古丁对多次剂量的行为敏化。受试者为96只青春期晚期雄性大鼠（48只Fischer，48只刘易斯）。大鼠每天皮下注射尼古丁（0.2、0.4、0.7、1.4、2.8 mg/kg）或生理盐水，隔日注射后立即测量自发活动，以检查致敏性。在0.2、0.4、0.7和1.4 mg/kg尼古丁剂量下，两种大鼠品系均发生行为致敏，但刘易斯和费舍尔大鼠之间无差异。响应2.8 mg/kg尼古丁剂量的水平活动模式未反映出行为致敏。结果表明，尼古丁行为敏化发生在刘易斯和费舍尔大鼠，并没有两个大鼠品系之间的差异。可以得出结论，所报告的大鼠尼古丁摄入量、敏感性和偏好的品系差异并不是由大鼠尼古丁行为致敏的品系差异引起的。
Individuals with greater nicotine-reactivity may be more likely to initiate and maintain cigarette-smoking behavior than individuals with less nicotine-reactivity. In rats, behavioral sensitization reflects a progressive increase in the psychomotor response to drugs of abuse thought to result from neuroplasticity in brain regions that mediate their motivational effects. Studying nicotine behavioral sensitization in rats with differential nicotine preference and intake, such as Lewis and Fischer rats, may provide clues about the role of nicotine-reactivity in tobacco use. Rat strain differences in nicotine behavioral sensitization may contribute to strain differences in nicotine preference, sensitivity, and intake. In the present research, nicotine behavioral sensitization to multiple doses was examined in Lewis and Fischer rats. Subjects were 96 late adolescent male (48 Fischer, 48 Lewis) rats. Rats received subcutaneous injections of nicotine (0.2, 0.4, 0.7, 1.4, 2.8 mg/kg) or saline daily, and locomotor activity was measured immediately following injections on alternating days to examine sensitization. Behavioral sensitization occurred in both rat strains at the 0.2, 0.4, 0.7, and 1.4 mg/kg nicotine doses, but did not differ between Lewis and Fischer rats. The pattern of horizontal activity that occurred in response to the 2.8 mg/kg nicotine dose did not reflect behavioral sensitization. Results indicate that nicotine behavioral sensitization occurred in Lewis and Fischer rats, and did not differ between the two rat strains. It can be concluded that reported rat strain differences in nicotine intake, sensitivity, and preference do not result from rat strain differences in nicotine behavioral sensitization.