A transient N-O-linked Pauson-Khand strategy for the synthesis of the deschloro carbocyclic core of the palau'amines and styloguanidines
A transient N-O-linked Pauson-Khand strategy for the synthesis of the deschloro carbocyclic core of the palau'amines and styloguanidines
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DOI：
10.1021/ol0344063
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发表时间：
2003-06-26
期刊：
影响因子：
5.2
通讯作者：
Austin, DJ
中科院分区：
文献类型：
--
作者：
Koenig, SG;Miller, SM;Austin, DJ
已开发了帕劳胺和styloguanidines的去氯环戊基核的立体控制路线。该策略利用具有“瞬时N-O系链”的烯炔的分子内Pauson-Khand环化以非对映选择性方式构建五元碳环。
A stereocontrolled route to the deschloro cyclopentyl core of the palau'amines and styloguanidines has been developed. This strategy makes use of the intramolecular Pauson-Khand cyclization of an enyne with a "transient N-O tether" to construct a five-membered carbocycle in a diastereoselective fashion.