Plastic changes in the auditory cortex induced by intensive frequency discrimination training
Plastic changes in the auditory cortex induced by intensive frequency discrimination training
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DOI：
10.1097/00001756-200003200-00032
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发表时间：
2000-03-20
期刊：
影响因子：
1.7
通讯作者：
Pantev, C
中科院分区：
文献类型：
--
作者：
Menning, H;Roberts, LE;Pantev, C
采用奇数球法对受试者进行15次(3周以上)的辨频训练，分别在训练前、训练中和训练后3周测量1000 Hz纯音序列和1050、1010、1005 Hz变异音序列诱发的慢听觉诱发电位(波Nim)和失配场(MMF)。受试者的任务是通过与标准刺激的逐渐较小的频率偏移来检测不同的偏差。频率辨别力在第一周迅速改善，随后小幅但持续改善。在训练过程中，NLM和MMF对异常刺激的反应幅度增大。这种增强一直持续到训练结束，但在3周后下降。结果表明，训练频率的大脑皮层表达发生了可塑性重组。《神经报告》11：817-822(C)2000 Lippincott Williams&Wilkins.
The slow auditory evoked (wave NIm) and mismatch field (MMF) elicited by sequences of pure tones of 1000 Hz and deviant tones of 1050, 1010 and 1005 Hz were measured before, during and 3 weeks after subjects were trained at frequency discrimination for 15 sessions (over 3 weeks) using an odd-ball procedure. The task of the subject was to detect deviants differing by progressively smaller frequency shifts from the standard stimulus. Frequency discrimination improved rapidly in the first week and was followed by small but constant improvements thereafter. Nlm and MMF responses to the deviant stimuli increased in amplitude during training. This enhancement persisted until training was finished, but decreased 3 weeks later. The results suggest a plastic reorganization of the cortical representation for the trained frequencies. NeuroReport 11:817-822 (C) 2000 Lippincott Williams & Wilkins.