Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds
Silver as biocides in burn and wound dressings and bacterial resistance to silver compounds
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DOI：
10.1007/s10295-006-0139-7
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发表时间：
2006-07-01
影响因子：
3.4
通讯作者：
Silver, Gregg
中科院分区：
文献类型：
--
作者：
Silver, Simon;Phung, Le T.;Silver, Gregg
银产品因其有益效果而被使用了数千年，通常用于卫生，近年来作为烧伤、创伤和糖尿病溃疡伤口的抗菌剂。磺胺嘧啶银乳膏（Silvazine和Flamazine）是全球销售的外用软膏。近年来，已经引入了一系列具有缓释银化合物的伤口敷料，包括Acticoat、Actisorb银、Silverlon等。虽然这些通常被认为可用于控制细菌感染（以及抗真菌和病毒），但关键问题仍然存在，重要的是包括用于伤口和烧伤用途的不同银产品的相对功效以及对Ag+具有抗性的微生物的存在。这些都是需要进一步研究的有益产品，尽管每种产品都有缺点。近年来，细菌对Ag的抗性所涉及的基因（和蛋白质）已经被定义和研究。
Silver products have been used for thousands of years for their beneficial effects, often for hygiene and in more recent years as antimicrobials on wounds from burns, trauma, and diabetic ulcers. Silver sulfadiazine creams (Silvazine and Flamazine) are topical ointments that are marketed globally. In recent years, a range of wound dressings with slow-release Ag compounds have been introduced, including Acticoat, Actisorb Silver, Silverlon, and others. While these are generally accepted as useful for control of bacterial infections (and also against fungi and viruses), key issues remain, including importantly the relative efficacy of different silver products for wound and burn uses and the existence of microbes that are resistant to Ag+. These are beneficial products needing further study, although each has drawbacks. The genes (and proteins) involved in bacterial resistance to Ag have been defined and studied in recent years.