Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries
Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries
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DOI：
10.1007/s00125-018-4781-1
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发表时间：
2019-03-01
期刊：
影响因子：
8.2
通讯作者：
Lowe, William L., Jr.
中科院分区：
文献类型：
--
作者：
Kadakia, Rachel;Nodzenski, Michael;Lowe, William L., Jr.
目的/假设我们旨在确定多种族母婴二人组中母体代谢物与新生儿肥胖和高胰岛素血症的关联。方法对四个血统群体（北欧、非洲加勒比、墨西哥裔美国人和泰国）总共 1600 名母亲的空腹和 1 小时血清样本进行靶向和非靶向代谢组学分析。 参加高血糖和不良妊娠结局 (HAPO) 研究，在妊娠 28 周时接受 OGTT，其新生儿在出生时进行人体测量。 结果在这项观察性研究中，荟萃分析表明，不同血统群体中，母亲禁食和 1 小时代谢物与出生体重、脐带 C 肽和/或皮褶总和存在显着相关性。特别是，母亲空腹三酰甘油与新生儿皮褶总数有关。 1 小时时，多种氨基酸、脂肪酸和脂质代谢物与一种或多种新生儿结局相关。网络分析揭示了与脐带 C 肽和皮褶总和相关的空腹酰基肉碱、氨基酸、脂质和脂肪酸代谢物簇，并在 1 小时添加了支链和芳香族氨基酸。结论/解释妊娠期间的母体代谢组与新生儿结局相关。怀孕期间母体氨基酸、酰基肉碱、脂质和脂肪酸及其代谢物的水平与胎儿生长、肥胖和脐带C肽有关，与母体BMI和血糖水平无关。
Aims/hypothesisWe aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother-newborn dyads.MethodsTargeted and non-targeted metabolomics assays were performed on fasting and 1h serum samples from a total of 1600 mothers in four ancestry groups (Northern European, Afro-Caribbean, Mexican American and Thai) who participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, underwent an OGTT at 28weeks gestation and whose newborns had anthropometric measurements at birth.ResultsIn this observational study, meta-analyses demonstrated significant associations of maternal fasting and 1h metabolites with birthweight, cord C-peptide and/or sum of skinfolds across ancestry groups. In particular, maternal fasting triacylglycerols were associated with newborn sum of skinfolds. At 1h, several amino acids, fatty acids and lipid metabolites were associated with one or more newborn outcomes. Network analyses revealed clusters of fasting acylcarnitines, amino acids, lipids and fatty acid metabolites associated with cord C-peptide and sum of skinfolds, with the addition of branched-chain and aromatic amino acids at 1h.Conclusions/interpretationThe maternal metabolome during pregnancy is associated with newborn outcomes. Maternal levels of amino acids, acylcarnitines, lipids and fatty acids and their metabolites during pregnancy relate to fetal growth, adiposity and cord C-peptide, independent of maternal BMI and blood glucose levels.