A Large-Scale Serological Survey of Toxoplasma gondii Infection Among Persons Participated in Health Screening in Yunnan Province, Southwestern China
A Large-Scale Serological Survey of Toxoplasma gondii Infection Among Persons Participated in Health Screening in Yunnan Province, Southwestern China
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云南省健康筛查人员大规模弓形虫感染血清学调查
DOI：
10.1089/vbz.2018.2334
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Zou Feng-Cai
中科院分区：
文献类型：
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作者：
Li Zhao;Sun Chun-Yi;Yang Ren-Dan;Xu Chang-Jun;Chen Mei-Chen;Zhang Yun-Jiang;Cong Wei;Zhu Xing-Quan;Liu Yang;Zou Feng-Cai
在中国西南部的云南省，有关于动物弓形虫感染的调查报告。然而，有限的信息是关于T的流行病学。云南省健康体检人群弓形虫感染情况调查。2014年1月至2016年12月，进行了大规模和横断面血清学调查，以揭示T.在三家大医院参加健康筛查的人中，共收集64，533份血清样本，检测抗-T。用市售的酶联免疫吸附测定试剂盒检测弓形虫抗体。T.弓形虫感染率为6.67%（4306/64,533）。其中，3721人（5.77%，3721/64,533）仅免疫球蛋白G（IgG）阳性，473人（0.73%，473/64,533）仅免疫球蛋白M（IgM）阳性，112人（0.17%，112/64,533）IgG和IgM均阳性。女性感染率（6.83%，3167/46,389）高于男性（6.28%，1139/18,144）。T. 41-50岁年龄组感染率为10.60%（228/2150）（P< 0.001）。2014年、2015年和2016年的血清阳性率分别为6.39%（1083/16，946）、6.24%（1261/20，201）和7.16%（1962/27，386）。结果表明，T.摘要云南省人群中弓形虫感染较为普遍，是一个值得关注的公共卫生问题。因此，应采取综合措施进行防治。云南省人畜弓形虫感染情况。
Surveys ofToxoplasma gondiiinfection in animals have been reported in Yunnan province, southwestern China. However, limited information is available regarding the epidemiology ofT. gondiiinfection among persons participated in health screening in Yunnan. From January 2014 to December 2016, a large-scale and cross-sectional serological survey was conducted to reveal the seroprevalence ofT. gondiiinfection in persons participated in health screening in three major hospitals. A total of 64,533 serum samples were collected and anti-T. gondiiantibodies were examined by commercially available enzyme-linked immunosorbent assay kits. The total seroprevalence ofT. gondiiinfection was 6.67% (4306/64,533). Of these, 3721 persons (5.77%, 3721/64,533) were positive for Immunoglobulin G (IgG) only, 473 persons (0.73%, 473/64,533) were positive for Immunoglobulin M (IgM) only, and 112 persons (0.17%, 112/64,533) were positive for both IgG and IgM. Female seroprevalence (6.83%, 3167/46,389) was higher than male (6.28%, 1139/18,144). The highest seroprevalence ofT. gondiiinfection was found in the age range of 41–50 years (10.60%, 228/2150) (p< 0.001). The seroprevalence in 2014, 2015, and 2016 were 6.39% (1083/16,946), 6.24% (1261/20,201), and 7.16% (1962/27,386), respectively. The results showed thatT. gondiiinfection is common in persons participated in health screening in Yunnan province, which has significant public health concern. Thus, improved integrated measures should be executed to prevent and controlT. gondiiinfection humans and animals in Yunnan province.