Systematic Investigations of Different Cytosine Modifications on CpG Dinucleotide Sequences: The Effects on the B‑Z Transition
Systematic Investigations of Different Cytosine Modifications on CpG Dinucleotide Sequences: The Effects on the B‑Z Transition
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CpG 二核苷酸序列上不同胞嘧啶修饰的系统研究：对 B-Z 转变的影响
DOI：
10.1021/ja4107012
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Xiang Zhou
中科院分区：
文献类型：
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作者：
Shaoru Wang;Yuelin Long;Jiaqi Wang;Yushu Ge;Pu Guo;Yi Liu;Tian Tian;Xiang Zhou
我们首先展示了三种新报道的表观遗传修饰，包括5hmC， 5fC和5caC，对CpG二核苷酸dna的B-Z转换的独特影响。我们进行了详细的分析，并比较了它们的效果。我们进一步研究了交替氧化和交替还原对CpG二核苷酸十二烷B-Z跃迁的调控。
We have first demonstrated the distinctive effects of three newly reported epigenetic modifications, including 5hmC, 5fC, and 5caC, on B-Z transition of CpG dinucleotide DNAs. We have performed detailed assays and compared their effects. We further studied the regulation of B-Z transition of CpG dinucleotide dodecamers by alternating oxidation and alternating reduction.