Regulation of visual Wulst cell responsiveness by imprinting causes stimulus-specific activation of rostral cells.
Regulation of visual Wulst cell responsiveness by imprinting causes stimulus-specific activation of rostral cells.
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DOI：
10.1038/srep42927
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发表时间：
2017-02-23
影响因子：
4.6
通讯作者：
Ohki-Hamazaki H
中科院分区：
文献类型：
--
作者：
Nakamori T;Kato T;Sakagami H;Tanaka K;Ohki-Hamazaki H
在小鸡的印记行为可以诱导专门在孵化后的短时间内。在此期间，关于印记刺激的视觉信息被传递到端脑中的视觉Wulst（VW），该端脑对应于哺乳动物的视觉皮层，然后被传递到称为中间中皮层的记忆存储区域。这两个区域对于印记是不可或缺的。我们以前表明，印记训练改变了响应模式的大众的印记刺激，然而，精确的细胞分布和机制与这种改变的反应仍不清楚。在这里，我们表明，一个特定的人口的嘴VW细胞响应的印记刺激，通过分析的亚细胞定位的弧/arg3.1转录在VW细胞。GABA能小白蛋白（PV）细胞在该区域的背侧区域丰富，并且印迹训练使激活的PV阳性神经元的数量加倍。在背侧VW注射GABA（A）受体拮抗剂荷包牡丹碱，干扰了反应细胞的吻侧分布，从而导致印记缺乏。这些结果表明，激活的PV细胞限制VW细胞对背侧区域的反应，形成特定的印迹通路。
Imprinting behaviour in chicks can be induced exclusively during a short period after hatching. During this period, visual information on the imprinting stimulus is conveyed to the visual Wulst (VW) in the telencephalon, which corresponds to the visual cortex of mammals, and then to the memory-storing region known as the intermediate medial mesopallium. These two regions are indispensable for imprinting. We previously showed that imprinting training altered the response pattern of the VW to the imprinting stimulus; however, the precise distribution of cells and the mechanism involved with this altered response remains unclear. Here we showed that a specific population of rostral VW cells responded to the imprinting stimulus by analysing the subcellular localization of Arc/arg3.1 transcripts in VW cells. GABAergic parvalbumin (PV) cells are abundant in the dorsal region of this area, and imprinting training doubled the number of activated PV-positive neurons. An injection of bicuculline, a GABA(A) receptor antagonist, in the dorsal VW disturbed the rostral distribution of responsive cells and thus resulted in a lack of imprinting. These results suggest that activated PV cells restrict VW cells response to dorsal area to form a specific imprinting pathway.