Effects of intrabone marrow-bone marrow transplantation plus adult thymus transplantation on survival of mice bearing leukemia.
Effects of intrabone marrow-bone marrow transplantation plus adult thymus transplantation on survival of mice bearing leukemia.
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骨髓内-骨髓移植加成人胸腺移植对白血病小鼠生存的影响。
DOI：
10.1089/scd.2011.0358
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发表时间：
2012
影响因子：
4
通讯作者：
S. Ikehara
中科院分区：
文献类型：
--
作者：
Yuming Zhang;N. Hosaka;Yunze Cui;M. Shi;Ming Li;Qing Li;S. Ikehara
我们最近发现同种异体骨髓内骨髓-骨髓移植（IBM-BMT）联合同一供体的成人胸腺移植（ATT）对荷实体瘤小鼠有较好的治疗效果。在目前的研究中，我们检查了这种策略对白血病小鼠生存的影响。将1×10（6）个白血病细胞（EL-4，H-2（B））静脉注射到8周龄B6（H-2（B））小鼠体内1周后，对小鼠进行8戈伊照射，并通过IBM-BMT移植1×10（7）个来自8周龄BALB/c小鼠（H-2（d））的骨髓细胞（BMCs），伴或不伴供体淋巴细胞输注（DLI）或ATT。所有未治疗的小鼠在注射EL-4后70天内死亡。约40%的单独使用IBM-BMT治疗的患者在100天内死于肿瘤复发。与此相反，那些用IBM-BMT+DLI或ATT治疗的患者显示了最长的生存率，而没有白血病复发。此外，前者表现出较少的移植物抗宿主病（GVHD）比后者。用IBM-BMT+ATT处理的小鼠也显示出在用单独BMT处理的小鼠和用IBM-BMT+DLI处理的小鼠之间的效应记忆（EM）和中枢记忆（CM）细胞的中间百分比。IBM-BMT+ATT治疗组T细胞数量和功能增加，产生IL-2和IFN-γ。这些结果表明，IBM-BMT+ATT是有效的治疗白血病与强移植物抗白血病，而不增加GVHD的风险。
We recently found that allogeneic intrabone marrow-bone marrow transplantation (IBM-BMT) plus adult thymus transplantation (ATT) from the same donor is effective in mice bearing solid tumors. In the current study, we examined the effects of this strategy on the survival of mice with leukemia. One week after intravenous injection of 1×10(6) leukemic cells (EL-4, H-2(b)) into 8-week-old B6 (H-2(b)) mice, the mice were 8 Gy irradiated and transplanted with 1×10(7) bone marrow cells (BMCs) from 8-week-old BALB/c mice (H-2(d)) by IBM-BMT with or without donor lymphocyte infusion (DLI) or ATT. All the mice without treatment died within 70 days after injection of EL-4. About 40% of those treated with IBM-BMT alone died within 100 days due to tumor relapse. In contrast, those treated with IBM-BMT+DLI or ATT showed the longest survival rate without relapse of leukemia. In addition, the former showed less graft versus host disease (GVHD) than the latter. The mice treated with IBM-BMT+ATT also showed an intermediate percentage of effector memory (EM) and central memory (CM) cells between those treated with BMT alone and those treated with IBM-BMT+DLI. The numbers and functions of T cells increased in those treated with IBM-BMT+ATT with interleukin-2 and interferon-γ production. These results suggest that IBM-BMT+ATT is effective in the treatment of leukemia with strong graft versus leukemia without increased risk of GVHD.
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影响因子：
158.5
作者：
Markert, ML;Boeck, A;Mahaffey, SM
通讯作者：
Mahaffey, SM
影响因子：
12.8
作者：
Li M;Abraham NG;Vanella L;Zhang Y;Inaba M;Hosaka N;Hoshino S;Shi M;Ambrosini YM;Gershwin ME;Ikehara S
通讯作者：
Ikehara S
胸腺中的调节反馈通路。
DOI：
10.1016/s0167-5699(97)01150-x
发表时间：
1997
期刊：
Immunology today
影响因子：
--
作者：
Mehr,R;Perelson,AS;Fridkis-Hareli,M;Globerson,A
通讯作者：
Globerson,A
绝对 T 细胞受体重排多样性的测量。
影响因子：
2.2
作者：
Baum,PaulD;Young,JenniferJ;McCune,JosephM
通讯作者：
McCune,JosephM