Impact of Kidney Disease and Blood Pressure on the Development of Cardiovascular Disease An Overview From the Japan Arteriosclerosis Longitudinal Study
Impact of Kidney Disease and Blood Pressure on the Development of Cardiovascular Disease An Overview From the Japan Arteriosclerosis Longitudinal Study
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DOI：
10.1161/circulationaha.108.792903
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发表时间：
2008-12-16
期刊：
影响因子：
37.8
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Ninomiya, Toshiharu;Kiyohara, Yutaka;Ueshima, Hirotsugu
肾脏疾病与心血管疾病（CVD）的风险增加有关;然而，在亚洲人群中很少有设计良好的前瞻性研究。最近的流行病学研究表明，较低的血压水平可能与肾功能不全个体CVD风险增加有关。方法和结果-使用来自日本10个基于社区的队列研究的数据，我们进行了以下操作-共有30657名40至89岁的个体，没有预先存在的CVD或肾衰竭，并检查了肾小球减少与肾功能衰竭之间的关系。滤过率（GFR）和CVD的风险。在平均7.4年的随访中，727人经历了CVD。在GFR为60 - 89 mL的受试者中，年龄和性别校正的CVD发病率显著增加。min（-1）。1.73 m（-2）（4.3/1000人-年，P=0.002）和GFR
Background-Kidney disease is associated with an increased risk of cardiovascular disease (CVD); however, there have been few well-designed prospective studies of this issue in Asian populations. Recent epidemiological studies have suggested that a lower blood pressure level may be associated with an increased risk of CVD in individuals with kidney dysfunction.Methods and Results-Using data from 10 community-based cohort studies in Japan, we conducted follow-up on a total of 30 657 individuals 40 to 89 years of age without preexisting CVD or kidney failure and examined the relationship between reduced glomerular filtration rate (GFR) and the risk of CVD. During an average 7.4-year follow-up, 727 individuals experienced CVD. The age- and sex-adjusted incidence of CVD increased significantly in subjects with GFR of 60 to 89 mL . min(-1) . 1.73 m(-2) (4.3 per 1000 person-years, P=0.002) and in those with a GFR