NON-CYTOCIDAL NATURAL VARIANTS OF HUMAN IMMUNODEFICIENCY VIRUS ISOLATED FROM AIDS PATIENTS WITH NEUROLOGICAL DISORDERS
NON-CYTOCIDAL NATURAL VARIANTS OF HUMAN IMMUNODEFICIENCY VIRUS ISOLATED FROM AIDS PATIENTS WITH NEUROLOGICAL DISORDERS
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从患有神经系统疾病的艾滋病患者中分离出的人类免疫缺陷病毒的非杀伤性天然变种
DOI：
10.1016/s0140-6736(87)90826-9
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
Jennifer L. Moore
中科院分区：
文献类型：
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作者：
R. Anand;C. Reed;S. Forlenza;F. Siegal;T. Cheung;Jennifer L. Moore
为了解HIV介导的神经病理机制，从4例以中枢神经系统症状为主要表现的艾滋病患者中分离到5株病毒。通过抗原交叉反应和与HIV特异性抗体和DNA探针的核酸杂交，这些分离株被鉴定为HIV。研究了这些分离株的复制和细胞病变特性，并与淋巴结病相关病毒(HIVLAV)进行了比较。所有分离株具有与LAV相当的复制能力，但4株分离株不能杀死T4(CD-4)细胞。这种对HIV的非细胞杀伤性自然变异的分离增加了这样一种可能性，即在某些艾滋病病例中，神经疾病可能是由于对T4细胞无细胞毒性的HIV变异所致。结果还表明，病毒复制和细胞毒性在HIV中并不总是协调一致的功能。
To understand the mechanism of HIVmediated neuropathology five viral isolates were obtained from four AIDS cases with central nervous system manifestations as the primary involvement. The isolates were identified as HIVs by antigenic cross-reactivity and nucleic acid hybridisations to HIV-specific antibodies and DNA probes. The replication and cytopathic properties of these isolates were studied and compared with lymphadenopathy-associated virus (HIVLAV). All isolates had replication competence equivalent to LAV, but four isolates did not kill T4 (CD-4) cells. This isolation of non-cytocidal natural variants of HIV raises the possibility that in some AIDS cases the neurological disorders might be due to HIV variants that are non-cytocidal to T4 cells. The results also indicate that virus replication and cytotoxicity are not always concordant functions in HIV.