A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods
A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods
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DOI：
10.1089/107555302760253603
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发表时间：
2002-08-01
影响因子：
2.6
通讯作者：
Zhuang, D
中科院分区：
文献类型：
--
作者：
Kong, JA;Ma, L;Zhuang, D
目的：表征正常人类受试者手动和电针引起的大脑激活模式。设计：我们使用功能磁共振成像（fMRI）来研究涉及电针和手动针刺刺激的大脑区域。该研究采用了区组设计。每个功能运行由 5 分钟组成，从 1 分钟基线和两次 1 分钟刺激开始，两次刺激之间的间隔为 1 分钟。对每个受试者进行四次功能性运行，两次运行用于电针疗法，两次运行用于手动针灸。两种方式的顺序在受试者中是随机的。实验过程中，在左手大肠4（LI4，合谷）处进行针刺操作。对于每个受试者，在扫描开始之前，将针垂直于皮肤表面插入大约 1.0 cm 的深度。使用连续矩形波形（脉冲宽度 30 ms）以 3 Hz 的频率进行电针刺激。手动针灸时，以每分钟约180次（3 Hz）的速度手动顺时针和逆时针旋转针。受试者：11名惯用右手的正常健康成年人志愿者，其中男性6名，女性5名，年龄21-64岁参加实验。结果：结果显示，电针主要在中央前回、中央后回/顶下小叶和中央回产生fMRI信号增加。壳核/岛叶；相比之下，手工针刺操作使后扣带回、颞上回、壳核/岛叶的功能磁共振成像信号显着降低。结论：这些结果表明，手工针刺和电针刺激过程中涉及不同的大脑网络。这表明在手工针灸和电针疗法期间可能会招募不同的大脑机制。
Objectives: To characterize the brain activation patterns evoked by manual and electroacupuncture on normal human subjects.Design: We used functional magnetic resonance imaging (fMRI) to investigate the brain regions involved in electroacupuncture and manual acupuncture needle stimulation. A block design was adopted for the study. Each functional run consists of 5 minutes, starting with 1-minute baseline and two 1-minute stimulation, the interval between the two stimuli was 1 minute. Four functional runs were performed on each subject, two runs for electroacupuncture and two runs for manual acupuncture. The order of the two modalities was randomized among subjects. During the experiment, acupuncture needle manipulation was performed at Large Intestine 4 (LI4, Hegu) on the left hand. For each subject, before scanning started, the needle was inserted perpendicular to the skin surface to a depth of approximately 1.0 cm. Electroacupuncture stimulation was delivered using a continuous rectangular wave form (pulse width 30 ms) at a frequency of 3 Hz. For manual acupuncture, the needle was rotated manually clockwise and counter-clockwise at a rate of about 180 times per minute (3 Hz).Subjects: Eleven right-handed, normal, healthy volunteer adults, 6 male and 5 female, ages 21-64 participated in the experiment.Results: Results showed that electroacupuncture mainly produced fMRI signal increases in precentral gyrus, postcentral gyrus/inferior parietal lobule, and putamen/insula; in contrast, manual needle manipulation produced prominent decreases of fMRI signals in posterior cingulate, superior temporal gyrus, putamen/insula.Conclusion: These results indicate that different brain networks are involved during manual and electroacupuncture stimulation. It suggests that different brain mechanisms may be recruited during manual and electroacupuncture.