Xenon biosensor amplification via dendrimer-cage supramolecular constructs

Xenon biosensor amplification via dendrimer-cage supramolecular constructs
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DOI:
10.1021/ja061735s
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发表时间:
2006-05-17
影响因子:
15
通讯作者:
Frechet, Jean M. J.
Frechet, Jean M. J.
中科院分区:
化学1区
文献类型:
--
作者:
Mynar, Justin L.;Lowery, Thomas J.;Frechet, Jean M. J.

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用单个生物素片段合成了聚酰胺胺树状大分子,并与隐胺- a笼结合形成了超分子生物传感器结构。这些新的生物传感器放大了从极化氙获得的核磁共振信号,比原来的Xe生物传感器多8倍。
Polyamidoamine dendrimers were synthesized with a single biotin moiety and used with cryptophane-A cages to form supramolecular biosensor constructs. These new biosensors amplified the NMR signals obtained from polarized xenon 8 times more than the original Xe biosensor.