The expression and functions of glycoconjugates in neural stem cells.
The expression and functions of glycoconjugates in neural stem cells.
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DOI：
10.1093/glycob/cwm018
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发表时间：
2007-07
期刊：
影响因子：
4.3
通讯作者：
M. Yanagisawa;R. Yu
中科院分区：
文献类型：
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作者：
M. Yanagisawa;R. Yu
哺乳动物中枢神经系统由多种细胞组成，如神经元和神经胶质细胞。这些细胞是从一个共同的祖细胞，神经干细胞（NSC）。NSC被定义为未分化的神经细胞，其特征在于其高增殖潜力，同时保留自我更新和多能性的能力。携带碳水化合物抗原（包括糖蛋白、糖脂和蛋白聚糖）的糖缀合物主要位于细胞的质膜表面上，并且在细胞分化的各个阶段充当优异的生物标志物。此外，它们还在决定细胞命运如自我更新、增殖和分化方面发挥重要的功能作用。在这篇综述中，我们讨论了糖复合物和糖抗原在神经干细胞中的表达模式和可能的功能，重点是阶段特异性胚胎抗原-1，人类自然杀伤抗原-1，聚唾液酸神经细胞粘附分子，heparin-1，gp 130，硫酸软骨素蛋白聚糖，硫酸乙酰肝素蛋白聚糖，半胱氨酸蛋白酶抑制剂C，半乳糖凝集素-1，糖脂和Notch。
The mammalian central nervous system is organized by a variety of cells such as neurons and glial cells. These cells are generated from a common progenitor, the neural stem cell (NSC). NSCs are defined as undifferentiated neural cells that are characterized by their high proliferative potential while retaining the capacity for self-renewal and multipotency. Glycoconjugates carrying carbohydrate antigens, including glycoproteins, glycolipids, and proteoglycans, are primarily localized on the plasma-membrane surface of cells and serve as excellent biomarkers at various stages of cellular differentiation. Moreover, they also play important functional roles in determining cell fate such as self-renewal, proliferation, and differentiation. In the present review, we discuss the expression pattern and possible functions of glycoconjugates and carbohydrate antigens in NSCs, with an emphasis on stage-specific embryonic antigen-1, human natural killer antigen-1, polysialic acid-neural cell-adhesion molecule, prominin-1, gp130, chondroitin sulfate proteoglycans, heparan sulfate proteoglycans, cystatin C, galectin-1, glycolipids, and Notch.