Ferruginous bodies resolved by synchrotron XRF in a dog with peritoneal malignant mesothelioma
Ferruginous bodies resolved by synchrotron XRF in a dog with peritoneal malignant mesothelioma
复制标题
通过同步加速器 XRF 解析患有腹膜恶性间皮瘤的狗的铁色小体
DOI：
10.1007/s11356-018-3521-x
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发表时间：
2018
影响因子：
5.8
通讯作者：
L. Pascolo
中科院分区：
文献类型：
--
作者：
E. Pascotto;A. Gianoncelli;Carla Calligaro;Thomas Marcuzzo;M. Melato;C. Rizzardi;L. Pascolo
间皮瘤是一种主要与职业性石棉接触有关的恶性肿瘤。很少有报告描述它也出现在动物身上，主要与环境中的石棉有关。石棉暴露的特征组织学特征：石棉含有铁质小体，是形成在纤维和其他尘埃颗粒周围的铁基结构。在这里，我们提出了一个疑似间皮瘤的狗腹膜间皮瘤的临床病例，并对铁质小体进行了平行的组织学观察。为了可能将犬肿瘤与环境暴露联系起来，我们在两个不同的同步加速器上进行了X射线荧光(XRF)分析，以解析铁质小体的成分。虽然组织学检查诊断为管状乳头状间皮瘤，但XRF分析显示铁质小体含有硅颗粒，类似于外源性形成；然而，其形态不太可能是石棉纤维。我们推测，这只狗的腹膜间皮瘤可能与环境中接触非石棉材料有关。
Mesothelioma is a malignant tumor mainly correlated to occupational asbestos exposure. Rare reports describe its occurrence also in animals, mainly linked to asbestos in the environment. Asbestos exposure is demonstrated by the appearance of characteristic histological hallmarks: asbestos containing ferruginous bodies that are iron-based structures forming around fibers and also other dust particles. Here we present a clinical case of a suspect of mesothelioma in the peritoneum of a dog with parallel histological observation of ferruginous bodies. To possibly correlate the dog tumor to environmental exposure, we performed X-ray fluorescence (XRF) analyses at two different synchrotrons to resolve the ferruginous bodies’ composition. While the histological examination diagnoses a tubulo-papillary mesothelioma, the XRF analyses show that ferruginous bodies contain Si particles, resembling formations of exogenous origin; however, the morphology is unlikely that of asbestos fibers. We speculate that the peritoneal mesothelioma of this dog could be related to environmental exposure to non-asbestos material.