How does PKMζ maintain long-term memory?
How does PKMζ maintain long-term memory?
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DOI：
10.1038/nrn2949
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发表时间：
2011-01-01
影响因子：
34.7
通讯作者：
Sacktor, Todd C.
中科院分区：
文献类型：
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作者：
Sacktor, Todd C.
大多数有助于长期记忆的分子机制被发现是在学习后的短时间窗口内巩固信息，而不是在记忆存储期间保持信息。然而，随着发现突触的长时程增强是由持续活跃的蛋白激酶M Zeta(PKM Zeta)维持的，人们已经确定了一种可能的记忆存储机制。最近的研究表明，PKM Zeta可能会在突触和长期记忆中保存信息。
Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase M zeta (PKM zeta), a possible mechanism of memory storage has been identified. Recent research shows how PKM zeta might perpetuate information both at synapses and during long-term memory.