Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.
Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.
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DOI：
10.1517/17460440802661443
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发表时间：
2009-02
影响因子：
6.3
通讯作者：
Hamann MT
中科院分区：
文献类型：
--
作者：
Kevin Ii DA;Meujo DA;Hamann MT
随着多重耐药（MDR）病原体的不断出现，识别新候选药物面临着巨大的压力。羧基聚醚，也称为聚醚抗生素，是一类独特的化合物，对包括原生动物、细菌和病毒在内的多种关键传染病目标具有出色的效力。这些分子的主要特点是它们对几种 MDR 病原体的选择性和高效力。尽管已经发表了许多关于羧基聚醚抗生素的研究，但最近没有对该类药物的评论。本综述的目的是为读者提供聚醚抗生素的活性谱、作用机制、毒性以及作为对抗耐药传染病候选药物的潜力的概述。聚醚离子载体在控制耐药细菌和寄生虫感染方面显示出巨大的前景。尽管此类药物的使用历史悠久，但药物化学和药物优化研究的报道非常有限，因此为未来的这些机会敞开了大门。 Scifinder 和 PubMed 是用于查找与本综述主题相关的文章的主要搜索引擎。我们搜索中使用的关键词是评论中提出的 88 种化合物的具体名称，以及更通用的术语，如聚醚、离子载体、羧基聚醚和聚醚抗生素。
As multidrug-resistant (MDR) pathogens continue to emerge, there is a substantial amount of pressure to identify new drug candidates. Carboxyl polyethers, also referred to as polyether antibiotics, are a unique class of compounds with outstanding potency against a variety of critical infectious disease targets including protozoa, bacteria and viruses. The characteristics of these molecules that are of key interest are their selectivity and high potency against several MDR etiological agents. Although many studies have been published about carboxyl polyether antibiotics, there are no recent reviews of this class of drugs. The purpose of this review is to provide the reader with an overview of the spectrum of activity of polyether antibiotics, their mechanism of action, toxicity and potential as drug candidates to combat drug-resistant infectious diseases. Polyether ionophores show a high degree of promise for the potential control of drug-resistant bacterial and parasitic infections. Despite the long history of use of this class of drugs, very limited medicinal chemistry and drug optimization studies have been reported, thus leaving the door open to these opportunities in the future. Scifinder and PubMed were the main search engines used to locate articles relevant to the topic presented in the present review. Keywords used in our search were specific names of each of the 88 compounds presented in the review as well as more general terms such as polyethers, ionophores, carboxylic polyethers and polyether antibiotics.