IDENTIFICATION OF AN ANDROGEN-REPRESSED MESSENGER-RNA IN RAT VENTRAL PROSTATE AS CODING FOR SULFATED GLYCOPROTEIN-2 BY CDNA CLONING AND SEQUENCE-ANALYSIS
IDENTIFICATION OF AN ANDROGEN-REPRESSED MESSENGER-RNA IN RAT VENTRAL PROSTATE AS CODING FOR SULFATED GLYCOPROTEIN-2 BY CDNA CLONING AND SEQUENCE-ANALYSIS
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DOI：
10.1042/bj2570293
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发表时间：
1989-01-01
影响因子：
4.1
通讯作者：
LIAO, SS
中科院分区：
文献类型：
--
作者：
BETTUZZI, S;HIIPAKKA, RA;LIAO, SS
去势后大鼠腹侧前列腺中少量mRNA的浓度增加，然后在雄激素治疗后降低。由于特定基因表达的抑制在器官生长的调节中可能是重要的，我们克隆了雄激素抑制mRNA的cDNA，其浓度在去势后4天增加了17倍，并且这种增加通过雄激素治疗迅速逆转。通过序列分析，雄激素抑制的mRNA被鉴定为编码硫酸化糖蛋白2的mRNA。
The concentrations of a small number of mRNAs in the rat ventral prostate increase after castration and then decrease upon androgen treatment. Since the repression of specific gene expression may be important in the regulation of organ growth, we have cloned a cDNA for an androgen-repressed mRNA, the concentration of which increased 17-fold 4 days after castration, and this increase was reversed rapidly by androgen treatment. By sequence analysis the androgen-repressed mRNA was identified as that coding for sulphated glycoprotein 2.