NEONATAL THYMECTOMY INCREASES INCIDENCE OF SPONTANEOUS AND METHYLCHOLANTHRENE-ENHANCED THYROIDITIS IN RATS
NEONATAL THYMECTOMY INCREASES INCIDENCE OF SPONTANEOUS AND METHYLCHOLANTHRENE-ENHANCED THYROIDITIS IN RATS
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DOI：
10.1126/science.184.4133.162
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发表时间：
1974-01-01
期刊：
影响因子：
56.9
通讯作者：
ROSE, NR
中科院分区：
文献类型：
--
作者：
SILVERMAN, DA;ROSE, NR
在 16 周龄时，13% 未经治疗的水牛品系大鼠表现出自身免疫性甲状腺炎的迹象。喂食甲基胆蒽可使发病率增加至 42%。新生儿胸腺切除术显着增加了疾病的发生率，因此几乎所有（87%）未经治疗的动物和所有接受甲基胆蒽治疗的动物都出现了严重的疾病。有人提出胸腺对自身敏化发挥调节作用。
At 16 weeks of age, 13 percent of untreated Buffalo strain rats showed evidence of autoimmune thyroiditis. Feeding methylcholanthrene increased the incidence to 42 percent. Neonatal thymectomy significantly raised the incidence of disease so that almost all (87 percent) untreated and all methylcholanthrene-treated animals developed severe disease. It is proposed that the thymus exerts a regulatory effect on autosensitization.