Potential of nanoparticulate carriers for improved drug delivery via skin
Potential of nanoparticulate carriers for improved drug delivery via skin
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DOI：
10.1007/s40005-018-00418-8
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发表时间：
2019-09-01
影响因子：
5.5
通讯作者：
Kim, Jin-Ki
中科院分区：
文献类型：
--
作者：
Zeb, Alam;Arif, Sadia Tabassam;Kim, Jin-Ki
近几十年来，皮肤作为药物的递送途径引起了极大的关注，因为它避免了口服和胃肠外给药的许多限制。然而，皮肤的优异屏障性能是药物通过该途径有效转运的主要障碍。皮肤的最上层，“角质层”是最紧密的一层，负责提供大部分的阻力。这需要可逆地和瞬时地破坏角质层的阻力，以便在体循环或局部皮肤中达到治疗上有意义的水平。在过去的几十年中，已经开发了许多方法来改善通过角质层的有限药物渗透性。一种有前途的方法是使用纳米颗粒载体，因为它们不仅有助于药物通过皮肤递送，而且还避免了传统皮肤制剂的缺点。本文综述了用于局部和经皮给药的纳米微粒载体，包括常规脂质体、可变形脂质体、醇质体、囊泡和脂质纳米粒。特别强调了它们的组成、结构、渗透机制和最近的应用。所呈现的数据证明了这些纳米颗粒载体用于皮肤和透皮递送的潜力。
Skin as a delivery route for drugs has attracted a great attention in recent decades as it avoids many of the limitations of oral and parenteral administration. However, the excellent barrier property of skin is a major obstacle in the effective transport of drugs through this route. The topmost layer of skin, the "stratum corneum" is the tightest one and is responsible for most of the resistance offered. This necessitates breaching the resistance of the stratum corneum reversibly and transiently in order to achieve a therapeutically meaningful level in systemic circulation or local skin. In last few decades, a number of approaches have been developed to improve the limited drug permeability through stratum corneum. One promising approach is the use of nanoparticulate carriers as they not only facilitate drug delivery across skin but also avoid the drawbacks of conventional skin formulations. This review focuses on nanoparticulate carriers including conventional liposomes, deformable liposomes, ethosomes, niosomes and lipid nanoparticles developed for topical and transdermal drug delivery. A special emphasis is placed on their composition, structure, mechanism of penetration and recent application. The presented data demonstrate the potential of these nanoparticulate carriers for dermal and transdermal delivery.