CYTOKINES IN ADENOVIRAL DISEASE IN CHILDREN - ASSOCIATION OF INTERLEUKIN-6, INTERLEUKIN-8, AND TUMOR-NECROSIS-FACTOR-ALPHA LEVELS WITH CLINICAL OUTCOME
CYTOKINES IN ADENOVIRAL DISEASE IN CHILDREN - ASSOCIATION OF INTERLEUKIN-6, INTERLEUKIN-8, AND TUMOR-NECROSIS-FACTOR-ALPHA LEVELS WITH CLINICAL OUTCOME
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DOI：
10.1016/s0022-3476(05)81360-5
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发表时间：
1994-05-01
影响因子：
5.1
通讯作者：
GRINSTEIN, S
中科院分区：
文献类型：
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作者：
MISTCHENKO, AS;DIEZ, RA;GRINSTEIN, S
为了探讨腺病毒感染的致病机制，我们评估了38例腺病毒感染住院儿童血清样本中免疫球蛋白、抗腺病毒抗体、腺病毒特异性循环免疫复合物和细胞因子的总水平。根据患者的临床表现和转归，将感染分为(1)中度（I组，n = 10）、(2)重度（II组，n = 12）、(3)致死性（III组，n = 16）。大约60%的儿童IgM水平升高。16例III组患者中有7例最初检测到含igg的腺病毒特异性循环免疫复合物，其中4例血清补体第三组分水平低。III组10例患者中有3例出现初始抗腺病毒lgG抗体下降。血清白细胞介素-6在I组未检出（10例中均未检出），而在II组（12例中有7例，p = 0.016）和III组（16例中有13例，p = 0.016）中均有检出
To explore the pathogenic mechanisms involved in adenovirus infection, we evaluated total levels of immunoglobulins, antiadenovirus antibodies, adenovirus-specific circulating immune complexes, and cytokines in serum samples obtained from 38 hospitalized children with adenovirus infection. According to their clinical findings and outcome, the infections were classified as follows: (1) moderate (group I, n = 10), (2) severe (group II, n = 12), and (3) fatal (group III, n = 16). About 60% of the children had elevated IgM levels. IgG-containing adenovirus-specific circulating immune complexes were initially detected in 7 of 16 group III patients, 4 of whom had low serum levels of the third component of complement. A decrease in initial antiadenovirus lgG antibodies was observed in 3 of 10 patients in group III. Serum interleukin-6 was not detected in group I (none of 10), but was present in group II (7 of 12, p = 0.016) and group III (13 of 16, p