Immunocytochemical analysis of receptors for estrogen and progesterone in fine‐needle aspirates from human breast carcinomas
Immunocytochemical analysis of receptors for estrogen and progesterone in fine‐needle aspirates from human breast carcinomas
复制标题
人乳腺癌细针抽吸物中雌激素和孕激素受体的免疫细胞化学分析
作者：
L. Skoog;S. Humla;Saed Isaksson;E. Tani
使用单克隆抗体对44例原发性人乳腺癌细针抽吸物中的雌激素受体（ER）和孕激素受体（PgR）进行术前分析。细胞学标本中获得的半定量受体值与手术切除的肿瘤组织的酶免疫分析结果相关性良好（PgR r = 0.74; ER r = 0.75）。细胞学涂片显示ER和PgR的异质性肿瘤细胞分布分别在29和23例。结果表明，细胞学涂片中ER和PgR的测量是一种准确可靠的技术，可以在最小量的组织上进行。
Monoclonal antibodies were used for a preoperative analysis of estrogen receptors (ERs) and progesterone receptors (PgRs) in fine‐needle aspirates from 44 primary human breast carcinomas. The semiquantitative receptor values obtained in cytologic specimens correlated well with those from enzyme immunoassay analysis on surgically removed tumor tissue (r = 0.74 for PgR;r = 0.75 for ER). Cytologic smears showed a heterogenous tumor cell distribution of ER and PgR in 29 and 23 cases, respectively. The results suggest that measurement of the ER and PgR in cytologic smears is an accurate and reliable technique that can be performed on a minimum amount of tissue.