Relevance of intermediate-density lipoprotein cholesterol to Framingham risk score of coronary heart disease in middle-aged men with increased non-HDL cholesterol.
Relevance of intermediate-density lipoprotein cholesterol to Framingham risk score of coronary heart disease in middle-aged men with increased non-HDL cholesterol.
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非高密度脂蛋白胆固醇升高的中年男性中密度脂蛋白胆固醇与冠心病弗雷明汉风险评分的相关性。
DOI：
10.1016/j.ijcard.2013.06.023
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发表时间：
2013
影响因子：
3.5
通讯作者：
N. Tada
中科院分区：
文献类型：
--
作者：
Kumie Ito;H. Yoshida;H. Yanai;Hideo Kurosawa;Ryo Sato;D. Manita;Y. Hirowatari;N. Tada
背景非高密度脂蛋白（non-HDL）包括低密度脂蛋白（LDL）、中密度脂蛋白（IDL）、极低密度脂蛋白（VLDL）和乳糜微粒（CM）残基，其胆固醇水平已被证明比LDL-胆固醇水平更能预测冠心病（CHD）的发生，与甘油三酯（TG）水平无关。本研究探讨的相关性TG丰富的脂蛋白（IDL，VLDL，CM）的Fragrance风险评分（FRS）预测10年的CHD risk.MethodsLipoprotein公司（HDL，LDL，IDL，VLDL，CM）在日本男性（n = 487）进行了体检的胆固醇水平测定使用我们开发的阴离子交换高效液相色谱法（AEX-HPLC）。采用常规方法测定总胆固醇（TC）、甘油三酯（TG）、空腹血糖（FBS）和血红蛋白（Hb）A1 c。结果除CM-胆固醇外，低FRS组与高FRS组血脂水平差异有显著性（P < 0.0001），BMI、TC、TG、IDL-胆固醇、VLDL-胆固醇与FRS呈显著正相关。其中非高密度脂蛋白胆固醇（non-HDL-cholesterol，non多元逐步回归分析表明，除了非高密度脂蛋白胆固醇外，富含TG的脂蛋白中的低密度脂蛋白胆固醇与FRS显着相关，而与BMI无关。这些相关性的结果也同样发现，即使没有高脂血症，糖尿病和高血压的药物治疗的研究对象（n = 348）的一部分investigated.ConclusionsThese结果表明，IDL-胆固醇可能作为一个有用的标志物，在日本男性冠心病的风险增加非HDL-胆固醇。
BackgroundCholesterol levels of non-high-density lipoprotein (non-HDL), which contains low-density lipoprotein (LDL), intermediate-density lipoprotein (IDL), very low-density lipoprotein (VLDL) and chylomicron (CM) remnant, have been proven to perform a significant predictor of coronary heart disease (CHD) better than LDL-cholesterol regardless of triglyceride (TG) levels. The present study investigated the relevance of TG-rich lipoproteins (IDL, VLDL, CM) to Framingham risk score (FRS) predictive of 10-year CHD risk.MethodsLipoprotein profiles (cholesterol levels of HDL, LDL, IDL, VLDL, CM) in Japanese men (n = 487) who underwent medical check-up were determined by using our developed anion-exchange high performance liquid chromatography (AEX-HPLC). Total-cholesterol (TC), TG, fasting blood sugar (FBS) and hemoglobin (Hb) A1c were measured by routine methods. The lipoprotein profiles, non-HDL-cholesterol, TC, and TG were examined on these associations with FRS.ResultsThe lipid levels except for CM-cholesterol were significantly different between two groups (low FRS, < 10%; high FRS, ≥ 10%) (P < 0.0001), and body mass index (BMI), TC, TG, IDL-, and VLDL-cholesterol were significantly and positively correlated with FRS. Among them, the significant association of non-HDL-cholesterol to FRS was noted (r = 0.411, P < 0.0001). Multiple stepwise regression analysis shows that, in addition to non-HDL-cholesterol, IDL-cholesterol in TG-rich lipoproteins was significantly correlated with FRS in independently of BMI. These correlation results were similarly found even when the part of the study subjects (n = 348) without the drug therapy for hyperlipidemia, diabetes, and hypertension was investigated.ConclusionsThese results suggest that IDL-cholesterol may serve as a useful marker for CHD risk in Japanese men with increased non-HDL-cholesterol.
影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB