Electrophysiology of Ascaris muscle and anti-nematodal drug action
Electrophysiology of Ascaris muscle and anti-nematodal drug action
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DOI：
10.1017/s0031182000077945
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发表时间：
1996-01-01
期刊：
影响因子：
2.4
通讯作者：
Murray, I
中科院分区：
文献类型：
--
作者：
Martin, RJ;Valkanov, MA;Murray, I
三类驱虫药直接选择性作用于寄生线虫肌膜受体。这些组的驱虫药是：（1）尼古丁激动剂（左旋咪唑、噻嘧啶、莫仑太尔和oxantel），作用于线虫体肌的乙酰胆碱受体;（2）GABA激动剂，哌嗪，作用于线虫肌GABA受体;和（3）阿维菌素，打开线虫咽肌上的谷氨酸门控Cl-通道。肌肉和神经肌肉传递的电生理学和药理学的线虫寄生虫，猪蛔虫，概述和驱虫剂的影响，干扰传输描述。一些寄生线虫对驱虫药产生了抗药性，但其抗药性机制尚不清楚。
Three groups of anthelmintic drugs act directly and selectively on muscle membrane receptors of parasitic nematodes. These groups of anthelmintics are: (1) The Nicotinic Agonists (levamisole, pyrantel, morantel and oxantel) that act on acetylcholine receptors of nematode somatic muscle; (2) The GABA Agonist, piperazine, that acts on nematode muscle GABA receptors; and (3) The Avermectins that open glutamate gated Cl- channels on nematode pharyngeal muscle. The electrophysiology and pharmacology of muscle and neuromuscular transmission the nematode parasite, Ascaris suum, is outlined and effects of anthelmintics that interfere with transmission described. Resistance to anthelmintics has appeared in some parasitic nematodes but the mechanisms of this resistance remain to be determined.