C-Reactive Protein Levels in African Americans A Diet and Lifestyle Randomized Community Trial
C-Reactive Protein Levels in African Americans A Diet and Lifestyle Randomized Community Trial
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DOI：
10.1016/j.amepre.2013.05.011
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发表时间：
2013-10-01
影响因子：
5.5
通讯作者：
Blair, Steven N.
中科院分区：
文献类型：
--
作者：
Hebert, James R.;Wirth, Michael;Blair, Steven N.
背景：慢性炎症与非洲裔美国人（尤其是美国东南部）普遍存在的不良生活方式行为和多种慢性疾病有关。目的：本研究的目的是测试2009-2012年进行的以社区为基础的饮食、体育活动和减压干预对降低超重和肥胖非洲裔美国成年人血清c反应蛋白（CRP）的影响。方法：由非裔美国人教会成员和学术研究人员共同设计了一项随机对照试验干预。2012年底，回归（即混合）模型拟合，包括意向治疗和事后分析，以确定干预成功的重要预测因素。分别在3个月和1年时评估结果。结果：在基线时，在13个教会招募的159名个体，具有可评估的结果数据，平均为肥胖（BMI=33.1[+/- 7.1]），平均CRP水平为3.7 (+/- 3.9)mg/L。干预组腰臀比在3个月时（2%,p=0.03）和1年时（5%,p= 60%）均有下降，CRP在3个月时（0.8 mg/L）有显著下降（p=0.05），但1年后无变化。BMI和白细胞介素-6均无差异。结论：在超重/肥胖但其他方面“健康”的非裔美国教会成员中，CRP基线水平非常高，这种干预在3个月和12个月时显著降低了CRP，并降低了腰臀比，这是炎症总体风险和下游健康影响的重要人体测量预测指标。试验注册：本研究注册于www.clinicaltrials.gov NCT01760902。(C) 2013年美国预防医学杂志
Background: Chronic inflammation is linked to poor lifestyle behaviors and a variety of chronic diseases that are prevalent among African Americans, especially in the southeastern U.S.Purpose: The goal of the study was to test the effect of a community-based diet, physical activity, and stress reduction intervention conducted in 2009-2012 on reducing serum C-reactive protein (CRP) in overweight and obese African-American adults.Methods: An RCT intervention was designed jointly by members of African-American churches and academic researchers. In late 2012, regression (i.e., mixed) models were fit that included both intention-to-treat and post hoc analyses conducted to identify important predictors of intervention success. Outcomes were assessed at 3 months and 1 year.Results: At baseline, the 159 individuals who were recruited in 13 churches and had evaluable outcome data were, on average, obese (BMI=33.1 [+/- 7.1]) and had a mean CRP level of 3.7 (+/- 3.9) mg/L. Reductions were observed in waist-to-hip ratio at 3 months (2%, p=0.03) and 1 year (5%, p= 60% of intervention classes, there was a significant decrease in CRP at 3 months of 0.8 mg/L (p=0.05), but no change after 1 year. No differences were noted in BMI or interleukin-6.Conclusions: In overweight/obese, but otherwise "healthy," African-American church members with very high baseline CRP levels, this intervention produced significant reductions in CRP at 3 and 12 months, and in waist-to-hip ratio, which is an important anthropometric predictor of overall risk of inflammation and downstream health effects. Trial registration: This study is registered at www.clinicaltrials.gov NCT01760902. (C) 2013 American Journal of Preventive Medicine