A highly transmissible tuberculosis outbreak: the importance of bars
A highly transmissible tuberculosis outbreak: the importance of bars
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DOI：
10.1017/s0950268817002588
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发表时间：
2017-12-01
影响因子：
4.2
通讯作者：
Manonelles, A.
中科院分区：
文献类型：
--
作者：
Godoy, P.;Alseda, M.;Manonelles, A.
结核病在酒吧的传播很难研究。目的是描述一家公司的酒吧和其他休闲场所的大规模结核病爆发。对一起结核病暴发进行了描述性研究。接触者在索引病例的工作场所酒吧（五个接触圈）和其他娱乐场所（索引病例附近三个酒吧的社交网络）进行了研究。建议结核菌素皮试（TST）阳性（5 mm）的接触者进行胸部X线检查。潜伏性结核感染（LTBI）的风险采用调整后的比值比确定。使用线性趋势卡方检验确定剂量-反应关系。我们研究了316名在指示病例工作场所的接触者，发现了5例新的结核病病例。LTBI的患病率为57.9%（183/316），第一圈高于第五圈，分别为96.0%（24/25）和46.5%（20/43）（P <0.0001）。在3个社区酒吧的58名接触者中，检出2例肺结核患者，LTBI患病率为517%（30/58）。一名继发性结核病患者的两名子女患病。酒吧可能是结核病的传播场所，由于酒吧是社交活动的热门场所，应被视为潜在的接触场所。
The transmission of tuberculosis (TB) in bars is difficult to study. The objective was to describe a large TB outbreak in a company's bar and other leisure settings. A descriptive study of a TB outbreak was carried out. Contacts were studied in the index case's workplace bar (five circles of contacts) and other recreational areas (social network of three bars in the index case's neighbourhood). Chest X-rays were recommended to contacts with positive tuberculin skin tests (TST) (5 mm). The risk of latent tuberculosis infection (LTBI) was determined using an adjusted odds ratio. The dose-response relationship was determined using the chi-square test for linear trend. We studied 316 contacts at the index case's workplace and detected five new cases of TB. The prevalence of LTBI was 579% (183/316) and was higher in the first circle, 960% (24/25), and lower in the fifth, 465% (20/43) (P < 00001). Among 58 contacts in the three neighbourhood bars, two TB cases were detected and the LTBI prevalence was 517% (30/58). Two children of one secondary TB company patient became ill. Bars may be transmission locations for TB and, as they are popular venues for social events, should be considered as potential areas of exposure.