Vitamin A deficiency produces spatial learning and memory impairment in rats
Vitamin A deficiency produces spatial learning and memory impairment in rats
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DOI：
10.1016/s0306-4522(02)00423-2
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发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
Fadda, F
中科院分区：
文献类型：
--
作者：
Cocco, S;Diaz, G;Fadda, F
维生素A及其衍生物(维甲酸)在许多生理过程中起着重要的作用。最近发现高水平的细胞视黄醇结合蛋白I型免疫反应。成年啮齿动物中枢神经系统细胞维甲酸结合蛋白I型免疫反应和核维甲酸受体的存在，提示维甲酸可能在成年鼠脑内发挥重要作用。考虑到海马体在空间学习和记忆中的作用，我们评估了成年大鼠缺乏维生素A对这些功能的影响。经过12周的不含维生素A的饮食。训练大鼠完成放射臂迷宫任务，结果表明，这种饮食导致了空间学习和记忆任务的严重缺陷。当饮食中补充维生素A时，认知障碍完全恢复。我们还发现东莨菪碱引起的海马乙酰胆碱释放显著减少。使用微透析技术进行评估，并与喂食充足维生素A的大鼠相比，维生素缺乏的大鼠的CA1区海马核的大小缩小。这些结果表明，维生素A在学习和记忆过程中具有关键作用，与正常的海马体功能有关，(C)2002 IBRO。爱思唯尔科学有限公司出版。版权所有。
Vitamin A and its derivatives (retinoids) play important roles in many physiological processes. The recent finding of high levels of cellular retinol-binding protein type I immunoreactivity. cellular retinoic acid-binding protein type I immunoreactivity and the presence of nuclear retinoid receptors in the central nervous system of adult rodents suggests that retinoids may carry out important roles in the adult brain. In consideration of the role of the hippocampus in spatial learning and memory we evaluated the effect of vitamin A deprivation in adult rats on these functions. Following 12 weeks of vitamin A free diet. rats ere trained to acquire a radial-arm maze task, Results show that this diet induced a severe deficit in the spatial learning and memory task. The cognitive impairment was fully restored when vitamin A as replaced in the diet. We also found a significant decrease in hippocampal acetylcholine release induced by scopolamine. assessed using microdialysis technique, and a reduction in the size of hippocampal nuclei of CA1 region in vitamin-deficient rats, compared to rats fed with a vitamin A-sufficient diet. These results demonstrate that vitamin A has a critical role in the learning and memory processes linked to a proper hippocampal functioning, (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.