The association between digit ratio (2D:4D) and blood pressure 3 among children and adolescents
The association between digit ratio (2D:4D) and blood pressure 3 among children and adolescents
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儿童和青少年手指比例（2D：4D）与血压之间的关联3
DOI：
10.1038/s41440-018-0199-x
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发表时间：
2019
影响因子：
5.4
通讯作者：
lianguo FU
中科院分区：
文献类型：
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作者：
Yifei ZHANG;lianguo FU
指长比（2D：4D）是产前激素暴露水平的生物标志物;该生物标志物与产前雄激素暴露呈负相关，与产前雌激素暴露呈正相关。我们研究了手指比（2D：4D）与血压的相关性。对687名8-15岁青少年进行了以学校为基础的调查。测量无名指（4D）和食指（2D）、收缩压（SBP）、舒张压（DBP）、睾酮和雌二醇水平。调查了他们的饮食行为、体力活动和久坐活动时间。结果显示，2D：4D比值与收缩压、舒张压或睾酮在男孩和女孩中均无显著相关。但在男孩中，它与血清雌二醇水平呈显著正相关。2D、4D、指长比乘指数（MIDRL）、食指与无名指平均数（AIR）与收缩压呈显著正相关男孩β值分别为4.16、5.49、2.95、5.25，P< 0.01; βsin分别为3.43、2.71、3.02和3.36（P< 0.01），并通过睾酮与SBP间接相关（P< 0.05）。女生2D、4D、AIR通过睾酮与DBP呈间接相关（P< 0.05）。总之，手指长度指标和血压之间存在直接和间接的关联，这意味着产前激素水平可能与儿童和青少年的血压相关。
Digit ratio (2D:4D) is a biomarker of prenatal hormone exposure levels; this biomarker is negatively related to prenatal androgen exposure and positively related to prenatal estrogen exposure. We investigated the correlation between digit ratio (2D:4D) and blood pressure. A school-based survey of 687 adolescents aged 8–15 years was conducted. The ring finger (4D) and index finger (2D), systolic blood pressure (SBP), diastolic blood pressure (DBP), testosterone, and estradiol levels were measured. Their dietary behaviors and physical and sedentary activity time were surveyed. The results showed the 2D:4D ratio was not significantly related to SBP, DBP, or testosterone in boys and girls. However, it was significantly positively correlated with serum estradiol levels in boys. The 2D, 4D, multiplied index of digit ratio and length (MIDRL) and average of the index finger and ring finger (AIR) were directly related to SBP in both sexes (βsin boys were 4.16, 5.49, 2.95, and 5.25, respectively,P< 0.01;βsin girls were 3.43, 2.71, 3.02, and 3.36, respectively,P< 0.01) and were also indirectly associated with SBP through testosterone (P< 0.05). The 2D, 4D and AIR were indirectly related to DBP in girls through testosterone (P< 0.05). In conclusion, there were direct and indirect associations between finger-length indicators and blood pressure, which implies that prenatal hormone levels might be correlated with blood pressure in children and adolescents.