Contingent negative variation (CNV) associated with sensorimotor timing error correction
Contingent negative variation (CNV) associated with sensorimotor timing error correction
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DOI：
10.1016/j.neuroimage.2015.11.071
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发表时间：
2016-02-15
期刊：
影响因子：
5.7
通讯作者：
Lee, Kwang-Hyuk
中科院分区：
文献类型：
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作者：
Jang, Joonyong;Jones, Myles;Lee, Kwang-Hyuk
引言：检测和随后的纠正感觉运动的时间错误是适应行为的基础。使用头皮记录的事件相关电位（ERPs），我们试图找到ERP组件，是预测的错误纠正性能在节奏movements.Method：健康的右手参与者被要求同步他们的手指水龙头到一个定期的音调序列（每600毫秒），而EEG数据被连续记录。分析了15名参与者的数据。偶尔的不规则性被内置到刺激呈现时间：90毫秒之前（提前：负移）或之后（延迟：正移）的预期时间点。敲击条件交替与听力条件，其中相同的刺激序列，但参与者并没有tack.Results：行为错误纠正后立即观察到的转变，与一定程度的过度纠正与积极的转变。我们的刺激锁定ERP数据分析显示，1）增加听觉N1振幅的正向移位条件和减少听觉N1调制的负向移位条件;和2）第二个增强负性（N2）在积极的条件下，与轻敲负条件相比。在反应锁定期，我们观察到一个CNV（contingent negative variation）样的负波，与轻敲阳性条件相比，在轻敲阴性条件下具有更早的潜伏期。这种CNV样的负峰值在周围的发病随后轻敲，与较早的峰值，更好的纠错性能与负的位移，而后来的峰值，更好的纠错性能与positiveshifts.Discussion：这项研究表明，CNV样的负性与纠错性能在我们的感觉运动同步研究。听觉N1和N2在负性与正性错误纠正中有差异。然而，我们没有发现他们参与行为错误纠正的证据。总的来说，我们的研究提供了进一步研究CNV在知觉和运动计时中的作用的基础。(C)2015 Elsevier Inc. All rights reserved.
Introduction: Detection and subsequent correction of sensorimotor timing errors are fundamental to adaptive behavior. Using scalp-recorded event-related potentials (ERPs), we sought to find ERP components that are predictive of error correction performance during rhythmic movements.Method: Healthy right-handed participants were asked to synchronize their finger taps to a regular tone sequence (every 600ms), while EEG data were continuously recorded. Data from 15 participants were analyzed. Occasional irregularities were built into stimulus presentation timing: 90 ms before (advances: negative shift) or after (delays: positive shift) the expected time point. A tapping condition alternated with a listening condition in which identical stimulus sequence was presented but participants did not tap.Results: Behavioral error correction was observed immediately following a shift, with a degree of over-correction with positive shifts. Our stimulus-locked ERP data analysis revealed, 1) increased auditory N1 amplitude for the positive shift condition and decreased auditory N1 modulation for the negative shift condition; and 2) a second enhanced negativity (N2) in the tapping positive condition, compared with the tapping negative condition. In response-locked epochs, we observed a CNV (contingent negative variation)-like negativity with earlier latency in the tapping negative condition compared with the tapping positive condition. This CNV-like negativity peaked at around the onset of subsequent tapping, with the earlier the peak, the better the error correction performance with the negative shifts while the later the peak, the better the error correction performance with the positive shifts.Discussion: This study showed that the CNV-like negativity was associated with the error correction performance during our sensorimotor synchronization study. Auditory N1 and N2 were differentially involved in negative vs. positive error correction. However, we did not find evidence for their involvement in behavioral error correction. Overall, our study provides the basis from which further research on the role of the CNV in perceptual and motor timing can be developed. (C) 2015 Elsevier Inc. All rights reserved.