Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles
Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles
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DOI：
10.1021/acsmacrolett.1c00643
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发表时间：
2022-02-15
影响因子：
7.015
通讯作者：
Ebara, Mitsuhiro
中科院分区：
文献类型：
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作者：
Nakagawa, Yasuhiro;Lee, Jeonggyu;Ebara, Mitsuhiro
磷脂酰丝氨酸（PtdSer）是凋亡细胞所暴露的磷脂之一，已成为通过将炎性小胶质细胞（Mi1）极化为抗炎表型（Mi2）来进行抗炎治疗的一种物质。在本研究中，我们报告了暴露PtdSer的聚合物颗粒（PSPs）对小胶质细胞极化的影响。在体外和体内实验中，PSPs通过上调过氧化物酶体增殖物激活受体γ，上调了Mi2型小胶质细胞并抑制了Mi1型小胶质细胞。本研究凸显了PSPs在抗炎治疗方面的潜力。
Phosphatidylserine (PtdSer), one of the phospholipids that the apoptotic cell exposes, has emerged for anti-inflammatory therapy via polarizing inflammatory microglia (Mi1) to anti-inflammatory phenotype (Mi2). In this study, we report microglia polarization effect of PtdSer-exposing polymeric particles (PSPs). PSPs upregulated Mi2 microglia and suppressed Mi1 microglia through peroxisome proliferatoractivated receptor gamma upregulation in vitro and in vivo. This study highlights the potential of PSPs for anti-inflammatory therapy.