Base-catalyzed N-N bond cleavage of hydrazones: synthesis of α-amino ketones.
Base-catalyzed N-N bond cleavage of hydrazones: synthesis of α-amino ketones.
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DOI：
10.1002/asia.201400037
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发表时间：
2014-05
期刊：
影响因子：
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通讯作者：
Hai-Tao Tang;Yun-Bing Zhou;Yu Zhu;Hong‐Chao Sun;Min Lin;Zhuang-Ping Zhan
中科院分区：
文献类型：
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作者：
Hai-Tao Tang;Yun-Bing Zhou;Yu Zhu;Hong‐Chao Sun;Min Lin;Zhuang-Ping Zhan
以肼、醛和α-卤代酮为起始原料，通过缩合/亲核取代/N-N键断裂级联反应，在Cs2 CO 3促进下合成了α-氨基酮。羰基在这种新的N-N键断裂过程中起着关键作用。
An efficient Cs2CO3-promoted synthesis of α-amino ketones using hydrazines, aldehydes, and α-haloketones as starting materials through a cascade condensation/nucleophilic substitution/N-N bond cleavage route is developed. The carbonyl group plays a key role in this novel N-N bond cleavage process.