Cutting edge:: In contrast to effector T cells, CD4+CD25+ FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death
Cutting edge:: In contrast to effector T cells, CD4+CD25+ FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death
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DOI：
10.4049/jimmunol.175.1.32
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发表时间：
2005-07-01
影响因子：
4.4
通讯作者：
Suri-Payer, E
中科院分区：
文献类型：
--
作者：
Fritzsching, B;Oberle, N;Suri-Payer, E
CD 4（+）CD 25（+）FoxP 3（+）调节性T细胞（T-reg）抑制T细胞功能并保护啮齿动物免受自身免疫性疾病的侵害。在免疫应答期间调节T-reg是非常重要的。增强T-reg的存活在自身免疫疾病中是有益的，而在癌症中通过凋亡增加消耗是有利的。我们在这里表明，新鲜分离的FACS分选的T-reg对CD 95介导的凋亡高度敏感，而其他T细胞群在分离后不久对CD 95诱导的凋亡具有抗性。相反，与CD 4（+）CD 25（-）T细胞相比，T-reg在体外reg中的TCR再刺激显示对活化诱导的细胞死亡的敏感性降低。因此，与reg其他T细胞相比，T细胞的凋亡表型是独特的，这可能进一步探索Treg的新的治疗调节。
CD4(+) CD25(+) FoxP3(+) regulatory T cells (T-reg) suppress T cell function and protect rodents from autoimmune disease. Regulation of T-reg during an immune response is of major importance. Enhanced survival of T-reg is beneficial inautoimmunedisease, where as increased depletion by apoptosis is advantageous in cancer. We show here that freshly isolated FACS-sorted T-reg are highly sensitive toward CD95-mediated apoptosis, whereas other T cell populations are resistant to CD95-induced apoptosis shortly after isolation. In contrast, TCR restimulation of T-reg in vitro reg revealed a reduced sensitivity toward activation-induced cell death compared with CD4(+) CD25(-)T cells. Thus, the apoptosis phenotype of T is unique in comparison to reg other T cells, and this might be further explored for novel therapeutic modulations of Treg.