First Total Synthesis of Murrastifoline B and an Improved Route to Murrastifoline F
First Total Synthesis of Murrastifoline B and an Improved Route to Murrastifoline F
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DOI：
10.1055/s-0033-1338621
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发表时间：
2014-06-01
期刊：
影响因子：
2
通讯作者：
Knoelker, Hans-Joachim
中科院分区：
文献类型：
--
作者：
Boerger, Carsten;Schmidt, Arndt W.;Knoelker, Hans-Joachim
本文报道了首次全合成murrastifoline B，并以双钯催化Buchwald-Hartwig胺化为关键步骤改进了murrastifoline F的合成路线。单体咔唑和联芳基前驱体也通过钯催化偶联反应制备。
We report the first total synthesis of murrastifoline B and an improved route to murrastifoline F using a twofold palladium-catalyzed Buchwald-Hartwig amination as key step. The monomeric carbazole and the biaryl precursor are also prepared via palladium-catalyzed coupling reactions.