Effect of warfarin anticoagulant rodenticide on the blood cell counts of Rattus norvegicus and Rattus rattus.
Effect of warfarin anticoagulant rodenticide on the blood cell counts of Rattus norvegicus and Rattus rattus.
复制标题
华法林抗凝灭鼠剂对褐家鼠和家鼠血细胞计数的影响。
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Y. M. Abdel
中科院分区：
文献类型：
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作者：
M. Mikhail;Y. M. Abdel
在实验室研究了华法林LD50对挪威大鼠、褐家鼠和屋脊鼠、吉萨省和卡里奥比亚省的大鼠血细胞计数的影响。与对照组相比，华法林中毒导致治疗大鼠的血细胞计数显著不同。华法林可显著降低模型大鼠的红细胞总数，升高白细胞总数。但中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞和单核细胞明显减少，而淋巴细胞显著增加。数据还显示，在存活的大鼠中，治疗后33/43天，WBC计数等于或略高于正常水平。
The effect of the warfarin LD50 on the counts of the blood cells of Norway rat, Rattus norvegicus and roof rat, Rattus rattus from Giza and Qualyobia Governorates was investigated in the laboratory. Warfarin toxication caused significantly different blood cell counts in treated rats compared to control ones. Warfarin significantly decreased the total erythrocytic count and increased the total leucocytic count of treated rats. But, it caused significant de-crease in neutrophrils, eosinophils, basophils and monocytes, but significant increase in lymphocytes. The data also showed that in survived rats, WBC count equaled the normal level or slightly exceeded it at 33/43 days post treatment.