Primary structure of the Herpesvirus ateles genome
Primary structure of the Herpesvirus ateles genome
复制标题
DOI：
10.1128/jvi.74.2.1033-1037.2000
复制
发表时间：
2000-01-01
影响因子：
5.4
通讯作者：
Albrecht, JC
中科院分区：
文献类型：
--
作者：
Albrecht, JC
疱疹病毒Ateles是蜘蛛猴（Ateles spp）固有的一种病原体，会导致各种新大陆灵长类动物发生暴发性淋巴瘤。结构和遗传相关性导致该病毒被分类为拉丁病毒属的成员。它与松鼠猴疱疹病毒关系最密切。疱疹病毒ateles株73基因组的108，409-bp轻链DNA片段具有两个U-RNA样转录物基因和73个开放阅读框，其中至少6个显示与细胞基因（编码补体控制蛋白、增殖调节蛋白、D型细胞周期蛋白、白细胞介素-8受体和参与核苷酸代谢的酶）显著同源。轻链DNA片段的左端区域携带假定的鼻病毒癌基因tio。
Herpesvirus ateles is an agent indigenous to spider monkeys (Ateles spp,) and causes fulminant lymphomas in various New World primates. Structural and genetic relatedness led to the classification of this virus as a member of the genus Rhadinovirus. It is most closely related to Herpesvirus saimiri. The 108,409-bp light DNA segment of the herpesvirus ateles strain 73 genome has two genes for U-RNA-like transcripts and 73 open reading frames, of which at least 6 show significant homologies to cellular genes (encoding complement control proteins, apoptosis-regulatory proteins, D-type cyclins, interleukin-8 receptors, and enzymes involved in nucleotide metabolism). The left terminal region of the light DNA segment bears the putative rhadinovirus oncogene tio.