GABAA receptor α1 and β2 subunit null mutant mice:: Behavioral responses to ethanol
GABAA receptor α1 and β2 subunit null mutant mice:: Behavioral responses to ethanol
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DOI：
10.1124/jpet.103.049478
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发表时间：
2003-06-01
影响因子：
3.5
通讯作者：
Harris, RA
中科院分区：
文献类型：
--
作者：
Blednov, YA;Walker, D;Harris, RA
测试缺乏GABA（A）受体α 1或β 2亚基的小鼠的乙醇、糖精或奎宁摄入量、乙醇条件性位置偏好、乙醇条件性味觉厌恶、乙醇模拟运动活动以及长期摄入乙醇液体饮食后处理诱导的癫痫发作。α 1无效突变体表现出减少乙醇和糖精的消耗，增加厌恶乙醇，和一个显着的刺激运动活动后注射乙醇。β 2无效突变体显示糖精和奎宁的消耗减少，但不显示乙醇的消耗减少。令人惊讶的是，没有突变体显示出显着的变化，在处理诱导癫痫发作之前或之后撤出乙醇。根据不同群体GABA（A）受体的不同变化，讨论了这两个GABA（A）受体亚基缺失对乙醇反应的独特影响。
Mice lacking either the alpha1 or beta2 subunit of the GABA(A) receptor were tested for ethanol, saccharin, or quinine consumption, ethanol-conditioned place preference, ethanol-conditioned taste aversion, ethanol-simulated motor activity, and handling-induced seizures following chronic consumption of an ethanol liquid diet. The alpha1 null mutants showed decreased ethanol and saccharin consumption, increased aversion to ethanol, and a marked stimulation of motor activity after injection of ethanol. The beta2 null mutants showed decreased consumption of saccharin and quinine, but not ethanol. Surprisingly, neither mutant showed marked changes in handling induced seizures before or after withdrawal of ethanol. The unique effects of deletion of these two GABA(A) receptor subunits on ethanol responses are discussed in terms of the distinct changes in different populations of GABA(A) receptors.