Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats
Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats
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DOI：
10.1016/j.etp.2008.04.016
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Ozgunes, H.
中科院分区：
文献类型：
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作者：
Atasayar, S.;Gurer-Orhan, H.;Ozgunes, H.
在这项研究中。研究了氨基胍对单剂量顺铂肾毒性的抗氧化作用，并与众所周知的抗氧化剂维生素 C 和 E 组合的作用进行了比较。在顺铂给药组的肾脏样本中观察到肾小管损伤和血管周围炎症。发现氨基胍和维生素 C-E 组合能够防止顺铂的这些影响。所有组的肝组织均完整。肾脏样本中谷胱甘肽显着减少和丙二醛水平显着增加证明了顺铂诱导的氧化应激。顺铂抗氧化剂降低了丙二醛水平。顺铂抗氧化剂可防止肝脏谷胱甘肽水平下降。通过血清尿素和肌酐水平显着升高，从生化角度证实了肾毒性。根据顺铂组的数据，维生素 C-E 组合和氨基胍均可防止血清尿素水平升高。 (C) 2008 爱思唯尔有限公司。版权所有。
In this study. the antioxidant effect of aminoguanidine on nephrotoxicity of a single dose of cisplatin is investigated and compared with the effects of well-known antioxidants vitamin C and E combination. Tubular damage and perivascular inflammation were observed in kidney samples of the cisplatin-administered groups. Aminoguanidine and vitamin C-E combination are found to be capable of preventing these effects of cisplatin. Liver tissues Of all groups were intact. Cisplatin-induced oxidative stress was evidenced by significant decrease in glutathione and significant increase in malondialdehyde levels in kidney samples. Antioxidants with cisplatin decreased malondialdehyde levels. Antioxidants with cisplatin prevented the decrease in liver glutathione levels. The nephrotoxicity was confirmed biochemically, by significant elevation of serum urea and creatinine levels. Both vitamin C-E combination and aminoguanidine prevented the increase in serum urea levels according to the cisplatin group. (C) 2008 Elsevier GmbH. All rights reserved.