Parental feeding and childhood genetic risk for obesity: exploring hypothetical interventions with causal inference methods.
Parental feeding and childhood genetic risk for obesity: exploring hypothetical interventions with causal inference methods.
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父母喂养与儿童肥胖遗传风险：用因果推理方法探索假设干预。
DOI：
10.1038/s41366-022-01106-2
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发表时间：
2022-07
影响因子：
4.9
通讯作者：
De Stavola, Bianca L.
中科院分区：
文献类型：
--
作者：
Herle, Moritz;Pickles, Andrew;Micali, Nadia;Abdulkadir, Mohamed;De Stavola, Bianca L.
父母喂养行为是儿童肥胖的常见干预目标，但通常只能带来很小的改变。儿童期体重指数部分是由遗传效应驱动的，父母喂养干预在多大程度上可以调节儿童的遗传倾向尚不清楚。在这里，我们的目的是使用因果推理方法，研究对父母喂养行为的潜在干预措施如何减轻儿童遗传倾向与青春期早期体重指数之间的某些关联。雅芳父母和儿童纵向研究的数据用于估计 12 岁时儿童 BMI 多基因评分 (PGS-BMI) 的干预差异测量。该方法比较了 10-11 岁儿童对父母喂养方式采用的不同假设干预措施的反事实结果 (n = 4248)。结果以遗传倾向 (PGS-BMI) 和 12 岁时 BMI 之间的调整总关联 (Adj-Ta) 与干预差异测量直接效应 (IDM-DE) 表示，后者代表了如果我们在不同情况下对父母喂养进行干预，仍将存在的关联。对于遗传倾向前五分位的儿童，将父母喂养转向遗传风险最低儿童水平的干预措施导致 12 岁时 BMI 差异为 0.81kg/m2（Adj-Ta = 3.27，95% CI：3.04，3.49；与 IDM-DE = 2.46，95% CI：2.24， 2.67）。研究结果表明，父母喂养干预措施有可能减轻儿童肥胖的部分遗传因素。此外，我们强调了一种新颖的方法，通过结合统计遗传学和社会流行病学的方法，仅使用二次数据分析来分析健康状况的潜在干预措施。
Parental-feeding behaviors are common intervention targets for childhood obesity, but often only deliver small changes. Childhood BMI is partly driven by genetic effects, and the extent to which parental-feeding interventions can mediate child genetic liability is not known. Here we aim to examine how potential interventions on parental-feeding behaviors can mitigate some of the association between child genetic liability and BMI in early adolescence, using causal inference methods. Data from the Avon Longitudinal Study of Parents and Children were used to estimate an interventional disparity measure for a child polygenic score for BMI (PGS-BMI) on BMI at 12 years. The approach compares counterfactual outcomes for different hypothetical interventions on parental-feeding styles applied when children are 10–11 years (n = 4248). Results are presented as adjusted total association (Adj-Ta) between genetic liability (PGS-BMI) and BMI at 12 years, versus the interventional disparity measure-direct effect (IDM-DE), which represents the association that would remain, had we intervened on parental-feeding under different scenarios. For children in the top quintile of genetic liability, an intervention shifting parental feeding to the levels of children with lowest genetic risk, resulted in a difference of 0.81 kg/m2 in BMI at 12 years (Adj-Ta = 3.27, 95% CI: 3.04, 3.49; versus IDM-DE = 2.46, 95% CI: 2.24, 2.67). Findings suggest that parental-feeding interventions have the potential to buffer some of the genetic liability for childhood obesity. Further, we highlight a novel way to analyze potential interventions for health conditions only using secondary data analyses, by combining methodology from statistical genetics and social epidemiology.
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影响因子：
8.8
作者：
Herle M;Smith AD;Kininmonth A;Llewellyn C
通讯作者：
Llewellyn C
DOI：
10.1136/bmj.e4759
发表时间：
2012-09-25
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
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通讯作者：
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影响因子：
8
作者：
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通讯作者：
Magarey, Anthea
DOI：
10.1186/s12966-020-00994-9
发表时间：
2020-07-25
影响因子：
8.7
作者：
Hesketh, Kylie D.;Salmon, Jo;Campbell, Karen J.
通讯作者：
Campbell, Karen J.
影响因子：
3.3
作者：
Korani, M.;Rea, D. M.;Brown, A. E.
通讯作者：
Brown, A. E.