A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom.
A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom.
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PET/MRI扫描仪进行多中心脑成像研究的资格途径：使用患者幻影评估基于MRI的衰减校正方法。
DOI：
10.2967/jnumed.120.261881
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Hope TA
中科院分区：
文献类型：
--
作者：
Catana C;Laforest R;An H;Boada F;Cao T;Faul D;Jakoby B;Jansen FP;Kemp BJ;Kinahan PE;Larson P;Levine MA;Maniawski P;Mawlawi O;McConathy JE;McMillan AB;Price JC;Rajagopal A;Sunderland J;Veit-Haibach P;Wangerin KA;Ying C;Hope TA
PET/MRI扫描仪不能以混合PET/CT器械所采用的方式进行鉴定。PET/MRI中的鉴定的主要障碍是在常规PET体模中不能充分地测量衰减校正（AC），因为难以转换物理结构的MR图像（例如，塑料）转换成电子密度图。在过去的十年中，已经开发了大量基于MRI的新算法，以更准确地推导出包括颅骨在内的人类头部的衰减特性。尽管前景看好，但这些技术中没有一种技术已成为PET/MRI中AC的最佳和普遍采用的策略。在这项工作中，我们提出了一个路径PET/MRI资格的多中心脑成像研究。具体而言，我们的解决方案是将头部AC与影响PET数据量化的其他因素分开，并使用患者作为体模来评估前者。应使用基于MRI和CT的AC方法重建待鉴定的集成PET/MRI扫描仪上收集的发射数据，并应进行全脑定性和定量（体素和区域）分析。如果PET定量偏倚在此处规定的验收标准范围内，则认为基于MRI的方法令人满意。我们已在2家研究中心的2家PET/MRI扫描仪制造商中成功实施了该方法。
PET/MRI scanners cannot be qualified in the manner adopted for hybrid PET/CT devices. The main hurdle with qualification in PET/MRI is that attenuation correction (AC) cannot be adequately measured in conventional PET phantoms because of the difficulty in converting the MR images of the physical structures (e.g., plastic) into electron density maps. Over the last decade, a plethora of novel MRI-based algorithms has been developed to more accurately derive the attenuation properties of the human head, including the skull. Although promising, none of these techniques has yet emerged as an optimal and universally adopted strategy for AC in PET/MRI. In this work, we propose a path for PET/MRI qualification for multicenter brain imaging studies. Specifically, our solution is to separate the head AC from the other factors that affect PET data quantification and use a patient as a phantom to assess the former. The emission data collected on the integrated PET/MRI scanner to be qualified should be reconstructed using both MRI- and CT-based AC methods, and whole-brain qualitative and quantitative (both voxelwise and regional) analyses should be performed. The MRI-based approach will be considered satisfactory if the PET quantification bias is within the acceptance criteria specified here. We have implemented this approach successfully across 2 PET/MRI scanner manufacturers at 2 sites.
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