The descent of memory T-cell subsets
The descent of memory T-cell subsets
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DOI：
10.1038/nri1866
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发表时间：
2006-08-01
影响因子：
100.3
通讯作者：
Marzo, Amanda
中科院分区：
文献类型：
--
作者：
Lefrancois, Leo;Marzo, Amanda
免疫系统通过不断增加其复杂性来进化，从而为宿主提供优于感染因子的优势。免疫记忆的形成产生持久的保护作用，延长宿主的寿命。记忆T细胞亚群的产生具有不同的归巢和功能特性，增强了我们的防御能力。然而，记忆t细胞亚群的发育关系是一个有争议的问题。在这篇观点文章中，根据最近的研究进展，我们认为可能有两种不同的谱系组成了响应感染而产生的记忆CD8(+) t细胞群。
The immune system has evolved by continuously increasing its complexity to provide the host with an advantage over infectious agents. The development of immunological memory engenders long-lasting protection and lengthens the lifespan of the host. The generation of subsets of memory T cells with distinct homing and functional properties increases our defensive capabilities. However, the developmental relationship of memory T-cell subsets is a matter of debate. In this Opinion article, in light of recent developments, we suggest that it is probable that two distinct lineages comprise the memory CD8(+) T-cell population generated in response to infection.