CD4-CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation
CD4-CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation
复制标题
CD4-CD8-T 细胞通过在免疫调节中实现微妙的平衡，促进病毒性肝炎的持续存在
DOI：
10.1016/j.cellimm.2012.11.010
复制
发表时间：
2012-11-01
影响因子：
4.3
通讯作者：
Ning, Qin
中科院分区：
文献类型：
--
作者：
Wang, Xiaojing;Yan, Weiming;Ning, Qin
病毒性肝炎仍然是肝脏疾病的最常见原因，也是一个主要的公共卫生问题。在这里，我们专注于CD 4-CD 8双阴性T（DN T）细胞参与肝炎病毒持续存在的机制中的作用。用小鼠肝炎病毒3株（MHV-3）感染C3 H/HeJ小鼠，以显示慢性病毒性肝炎。DN T细胞在MHV-3感染的小鼠中显著增加。从MHV-3感染的小鼠连续转移DN T细胞导致小鼠存活率显著增加。产生IFN-γ和IL-2的DN T细胞能够通过Fas/FasL依赖性途径杀伤病毒特异性CD 8（+）T细胞。DN T细胞多种效应的微妙平衡可能导致MHV-3诱导的肝炎中的病毒持续存在。简而言之，我们的研究确定了DN T细胞有助于C3 H/HeJ小鼠中MHV-3诱导的肝炎中的病毒持续存在，这为调节DN T细胞以管理病毒性肝炎提供了理论基础。(C)2012 Elsevier Inc. All rights reserved.
Viral hepatitis remains the most common cause of liver disease and a major public health problem. Here, we focus on the role of CD4 CD8 double negative T (DN T) cells involved in the mechanisms of viral persistence in hepatitis. C3H/HeJ mice infected with murine hepatitis virus strain 3 (MHV-3) were used to display chronic viral hepatitis. DN T cells dramatically increased in MHV-3 infected mice. Adoptive transfer of DN T cells from MHV-3 infected mice led to a significant increase in mice survival. The DN T cells with production of IFN-gamma and IL-2 are able to kill virus-specific CD8(+) T cells via the Fas/FasL dependent pathway. The delicate balance of multiple effects of DN T cells may lead to viral persistence in MHV-3 induced hepatitis. In short, our study identified DN T cells contributing to viral persistence in MHV-3 induced hepatitis in C3H/HeJ mice, which provides a rationale for modulating DN T cells for the management of viral hepatitis. (C) 2012 Elsevier Inc. All rights reserved.