Role of AMP-activated protein kinase in the control of appetite.
Role of AMP-activated protein kinase in the control of appetite.
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DOI：
10.1111/j.1365-2826.2008.01745.x
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发表时间：
2008-07
影响因子：
3.2
通讯作者：
Kola B
中科院分区：
文献类型：
--
作者：
Kola B
AMP活化蛋白激酶是调节能量代谢的关键酶。其活化在多种组织中具有多效性效应，包括增加脂肪酸氧化、葡萄糖摄取和糖酵解，以及抑制脂肪酸和糖原合成和糖原合成，以及刺激线粒体生物合成。近年来，AMP活化蛋白激酶（AMPK）也作为食欲调节剂出现，有助于控制细胞和全身水平的能量代谢。下丘脑AMPK的药理学和遗传学激活或抑制分别导致食物摄入增加或减少。AMPK似乎在下丘脑葡萄糖和营养感测中发挥作用，许多研究表明AMPK在介导各种内源性和外源性物质的食欲或厌食作用中发挥作用。
AMP-activated protein kinase is a key enzyme in the regulation of energy metabolism. Its activation has pleiotropic effects in multiple tissues, including increased fatty acid oxidation, glucose uptake and glycolysis, as well as the inhibition of fatty acid and glycogen synthesis and gluconeogenesis, and stimulation of mitochondrial biogenesis. Recently, the AMP-activated protein kinase (AMPK) has also emerged as a regulator of appetite, contributing to the control of energy metabolism at both cell and the whole body levels. Pharmacological and genetic activation or inhibition of hypothalamic AMPK lead to increased or reduced food intake, respectively. AMPK appears to play a role in hypothalamic glucose and nutrient sensing and numerous studies have suggested a role for AMPK in mediating the orexigenic or anorexigenic effects of various endogenous and exogenous substances.
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影响因子：
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通讯作者：
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